Fattoretti P, Viticchi C, Piantanelli L
Arch Gerontol Geriatr. 1982 Nov;1(3):229-40. doi: 10.1016/0167-4943(82)90024-3.
Beta-adrenergic receptors were characterized in submandibular glands of ageing mice and old mice grafted with a neonatal thymus. No statistically significant changes of receptor affinity were found in the animal models investigated. On the contrary, receptor density showed a progressive decrease with advancing age. The age-related decrease has been found partially corrected in thymus-grafted old animals, which show a statistically significant recovery of receptor density when compared to their untreated littermates. Receptor modulation can be responsible for the age-related impairment and the thymus-dependent correction of beta-adrenergic responsiveness of submandibular glands previously observed in vivo. Hormonal balance and thyroid hormones, in particular, are suggested as being involved in the age- and thymus-dependent regulation of receptor density. In the accompanying Appendix, we describe the mathematical method used to calculate both specific and nonspecific binding from total binding data.
对老龄小鼠以及移植了新生胸腺的老龄小鼠的颌下腺中的β-肾上腺素能受体进行了特性分析。在所研究的动物模型中，未发现受体亲和力有统计学意义的变化。相反，受体密度随着年龄的增长而逐渐降低。在移植胸腺的老龄动物中，已发现与年龄相关的降低得到了部分纠正，与未处理的同窝动物相比，其受体密度有统计学意义的恢复。受体调节可能是之前在体内观察到的颌下腺β-肾上腺素能反应性与年龄相关的损害以及胸腺依赖性纠正的原因。特别是激素平衡和甲状腺激素被认为参与了受体密度的年龄和胸腺依赖性调节。在随附的附录中，我们描述了用于从总结合数据计算特异性和非特异性结合的数学方法。
