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Phosphopeptide characterization by mass spectrometry using reversed-phase supports for solid-phase β-elimination/Michael addition.使用反相载体进行固相β-消除/迈克尔加成反应的质谱法对磷酸肽进行表征。
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Phosphorylation loops in synthetic peptides of the human neurofilament protein middle-sized subunit.
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本文引用的文献

1
Nuclear magnetic resonance studies of the conformation and kinetics of the peptide-substrate at the active site of bovine heart protein kinase.
Biochemistry. 1981 Feb 3;20(3):602-10. doi: 10.1021/bi00506a024.
2
The effect of counterions on melittin aggregation.抗衡离子对蜂毒肽聚集的影响。
Biochem J. 1983 Jun 1;211(3):683-6. doi: 10.1042/bj2110683.
3
Detection and identification of substrates for protein kinases: use of proteins and synthetic peptides.
Methods Enzymol. 1984;107:130-54. doi: 10.1016/0076-6879(84)07008-7.
4
The structural requirements of substrates of cyclic AMP-dependent protein kinase.
FEBS Lett. 1982 Mar 22;139(2):287-90. doi: 10.1016/0014-5793(82)80872-7.
5
The role of protein phosphorylation in neural and hormonal control of cellular activity.蛋白质磷酸化在细胞活动的神经和激素控制中的作用。
Nature. 1982 Apr 15;296(5858):613-20. doi: 10.1038/296613a0.
6
Phosphopeptide substrates of a phosphoprotein phosphatase from rat liver.大鼠肝脏磷酸蛋白磷酸酶的磷酸肽底物。
J Biol Chem. 1980 Dec 10;255(23):11339-43.
7
Computed circular dichroism spectra for the evaluation of protein conformation.用于评估蛋白质构象的计算圆二色光谱。
Biochemistry. 1969 Oct;8(10):4108-16. doi: 10.1021/bi00838a031.
8
Structure of bis(methylguanidinium) monohydrogen orthophosphate. A model for the arginine-phosphate interactions at the active site of staphylococcal nuclease and other phosphohydrolytic enzymes.
J Am Chem Soc. 1974 Jul 10;96(14):4471-8. doi: 10.1021/ja00821a020.
9
Solid-phase peptide synthesis.固相肽合成
Adv Enzymol Relat Areas Mol Biol. 1969;32:221-96. doi: 10.1002/9780470122778.ch6.
10
[Conformation studies on oligoalanines, substance P, and the myoglobin sequence (66-73). Circular dichroism of polyethyleneglycol-bound peptides].[寡聚丙氨酸、P物质及肌红蛋白序列（66 - 73）的构象研究。聚乙二醇结合肽的圆二色性]
Biopolymers. 1976 May;15(5):917-27. doi: 10.1002/bip.1976.360150508.

磷酸基团在3',5'-环磷酸腺苷依赖性蛋白激酶磷酸肽产物结构中的作用。

The role of the phosphate group for the structure of phosphopeptide products of adenosine 3',5'-cyclic monophosphate-dependent protein kinase.

作者信息

Hider R C, Ragnarsson U, Zetterqvist O

出版信息

Biochem J. 1985 Jul 15;229(2):485-9. doi: 10.1042/bj2290485.

DOI:10.1042/bj2290485
PMID:2994637
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1145081/
Abstract

By c.d. studies it is shown that liver-pyruvate-kinase-related peptide substrates of cyclic AMP-dependent protein kinase have a high tendency towards non-random structures in non-aqueous media. When phosphorylated, the conformation tendencies decrease. This structural change is explained in terms of the formation of strong intrapeptide phosphate-guanidinium salt links. It is proposed that similar events occur at the catalytic site of protein kinase and that such an interaction could facilitate the removal of the phosphorylated products.

摘要

通过圆二色性研究表明，环磷酸腺苷依赖性蛋白激酶的肝丙酮酸激酶相关肽底物在非水介质中具有形成非随机结构的强烈倾向。磷酸化后，构象倾向降低。这种结构变化可以用肽内强磷酸 - 胍盐键的形成来解释。有人提出，类似的事件发生在蛋白激酶的催化位点，并且这种相互作用可能有助于磷酸化产物的去除。