Cohen P
Nature. 1982 Apr 15;296(5858):613-20. doi: 10.1038/296613a0.
Protein phosphorylation is now recognized to be the major general mechanism by which intracellular events in mammalian tissues are controlled by external physiological stimuli. However, only recently has the idea that different cellular functions are controlled by common protein kinases and protein phosphatases started to gain widespread acceptance. Thus there is an integrated network of regulatory pathways, mediated by phosphorylation-dephosphorylation, that allows diverse cellular events to be coordinated by neural and hormonal stimuli. The evidence that supports this concept is reviewed, with emphasis on the role of protein phosphorylation in enzyme regulation.
蛋白质磷酸化现已被公认为是哺乳动物组织中细胞内事件受外部生理刺激控制的主要普遍机制。然而，直到最近，不同细胞功能由共同的蛋白激酶和蛋白磷酸酶控制这一观点才开始得到广泛认可。因此，存在一个由磷酸化-去磷酸化介导的调节途径整合网络，它能使各种细胞事件通过神经和激素刺激进行协调。本文综述了支持这一概念的证据，重点是蛋白质磷酸化在酶调节中的作用。
