Tatham A S, Hider R C, Drake A F
Biochem J. 1983 Jun 1;211(3):683-6. doi: 10.1042/bj2110683.
Melittin, a surface-active polypeptide from bee venom, has an overall hydrophobic N-terminus, with basic residues clustered at the C-terminus. In aqueous solution melittin exists as a mixture of monomer and tetramer, the monomer adopting a predominantly random-coil configuration, whereas the tetramer is rich in alpha-helix. The tendency of melittin to aggregate is dependent on the counter-anions present in solution, the effect being most marked with phosphate, decreasing in the order HPO4(2-) greater than SO4(2-) greater than ClO4- greater than Cl-.
蜂毒肽是一种来自蜂毒的表面活性多肽，其N端总体呈疏水性，碱性残基聚集在C端。在水溶液中，蜂毒肽以单体和四聚体的混合物形式存在，单体主要呈无规卷曲构象，而四聚体富含α-螺旋。蜂毒肽的聚集倾向取决于溶液中存在的抗衡阴离子，其中磷酸根的影响最为显著，按HPO4(2-)＞SO4(2-)＞ClO4-＞Cl-的顺序递减。
