ACL 重建后软骨的短期接触运动学变化和长期生化变化：一项初步研究。
Short-Term Contact Kinematic Changes and Longer-Term Biochemical Changes in the Cartilage After ACL Reconstruction: A Pilot Study.
机构信息
Orthopaedic Bioengineering Research Center, Newton-Wellesley Hospital and Harvard Medical School, Newton, MA, 02462, USA.
College of Health and Rehabilitation Sciences, Boston University, Boston, MA, 02215, USA.
出版信息
Ann Biomed Eng. 2018 Nov;46(11):1797-1805. doi: 10.1007/s10439-018-2079-6. Epub 2018 Jun 26.
Abstract
Investigation of the development of cartilage degeneration after ACL reconstruction is important for improving current surgical treatment of ACL injuries to prevent long-term knee joint degeneration. This pilot study examined the relationship between the changes in weight-bearing knee contact kinematics 6 months after ACL reconstruction and the biochemical composition changes in the knee cartilage measured using T2 relaxation values 3 years after the surgery in seven patients. The analysis indicated that the change of the knee contact kinematics in short-term after ACL reconstruction is associated with an increase of T2 values of the cartilage in longer follow up times. The data of this study could provide preliminary data to power future studies that use prospective, longitudinal research and large patient populations to establish prognostic biomechanical markers for determination of long-term cartilage degeneration after ACL reconstruction.
摘要
研究 ACL 重建后软骨退变的发展对于改进目前 ACL 损伤的手术治疗以预防长期膝关节退变非常重要。本初步研究检查了 7 例患者 ACL 重建后 6 个月时膝关节负重接触运动学变化与手术后 3 年时膝关节软骨 T2 弛豫值测量的生化成分变化之间的关系。分析表明，ACL 重建后短期膝关节接触运动学的变化与随访时间较长时软骨 T2 值的增加有关。本研究的数据可以提供初步数据，为未来的研究提供动力，这些研究将采用前瞻性、纵向研究和大的患者人群，以确定 ACL 重建后长期软骨退变的预后生物力学标志物。
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