Department of Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi-85, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.
Head Neck. 2018 Oct;40(10):2263-2270. doi: 10.1002/hed.25329. Epub 2018 Jun 26.
With the introduction of new American Joint Committee on Cancer (AJCC) classifications for head and neck cancers few cases are upgraded from T2 to T3 based only on depth of invasion. The role of adjuvant therapy in this particular subset of patients is still not defined.
This is a retrospective analysis of data from 2009 to 2015, of patients with histopathology of pT1, T2, and N0. A total of 375 patients were subdivided into 3 groups per the new AJCC classification depth of invasion <5 mm, 6 to 10 mm, and >10 mm. Survival analyses of patients receiving adjuvant therapy and those who did not were compared with specific emphasis on patients who were upstaged from T2 to T3 based on depth of invasion.
Depth of invasion is a poor prognostic factor and addition of adjuvant therapy based on depth of invasion did not have significant survival benefits.
Addition of adjuvant therapy based on depth of invasion does not influence survival in patients with early carcinoma of the tongue.
随着新的美国癌症联合委员会（AJCC）头颈部癌症分类的引入，仅有浸润深度的情况下，很少有 T2 期病例升级为 T3 期。在这部分特定患者中，辅助治疗的作用仍未确定。
这是对 2009 年至 2015 年病理为 pT1、T2 和 N0 的患者数据的回顾性分析。共有 375 例患者根据新的 AJCC 分类，浸润深度<5mm、6-10mm 和>10mm 分为 3 组。比较接受辅助治疗和未接受辅助治疗的患者的生存情况，并特别强调基于浸润深度从 T2 升级为 T3 的患者。
浸润深度是一个不良预后因素，基于浸润深度增加辅助治疗并没有显著的生存获益。
基于浸润深度增加辅助治疗并不影响舌早期癌患者的生存。
