侵袭深度可预测口腔舌鳞癌患者的淋巴结转移和生存情况。
Depth of invasion as a predictor of nodal disease and survival in patients with oral tongue squamous cell carcinoma.
机构信息
Department of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Department of Pathology, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
出版信息
Head Neck. 2019 Jan;41(1):177-184. doi: 10.1002/hed.25506. Epub 2018 Dec 7.
BACKGROUND
Depth of invasion (DOI) in oral cavity cancer is important in determining prognosis. This study aims to determine optimal cut-points of DOI for detection of occult disease and survival.
METHODS
A retrospective cohort study was completed of previously untreated early stage lateral oral tongue cancer. DOI cut-points were computed. Multiple logistic regression and multivariate Cox proportional hazards models were used to assess predictors of occult nodal disease and overall survival (OS) and disease-specific survival (DSS).
RESULTS
Occult nodal disease was found in 55 (26%) of the 212 patients. DOI of 7.25 mm was most predictive for occult nodal disease and 8 mm for OS and DSS. DOI was an independent predictor of OS and DSS.
CONCLUSION
The optimal DOI cut-point for detection of occult nodal metastasis was 7.25 and 8 mm for OS and DSS at 5 years. DOI is an independent predictor of OS and DSS.
背景
口腔癌的浸润深度（DOI）对于判断预后具有重要意义。本研究旨在确定 DOI 的最佳截断值，以检测隐匿性疾病和生存情况。
方法
本研究回顾性分析了未经治疗的早期外侧口腔舌癌患者的队列研究数据。计算了 DOI 截断值。采用多变量逻辑回归和多变量 Cox 比例风险模型来评估隐匿性淋巴结疾病以及总生存（OS）和疾病特异性生存（DSS）的预测因素。
结果
在 212 例患者中，有 55 例（26%）发现隐匿性淋巴结疾病。DOI 为 7.25mm 时最能预测隐匿性淋巴结疾病，而 8mm 时则能预测 OS 和 DSS。DOI 是 OS 和 DSS 的独立预测因素。
结论
最佳的 DOI 截断值为 7.25mm，用于检测隐匿性淋巴结转移；而对于 5 年的 OS 和 DSS，最佳的 DOI 截断值为 8mm。DOI 是 OS 和 DSS 的独立预测因素。
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