Yosefof Eyal, Edri Nofar, Kurman Noga, Bachar Gideon, Shpitzer Thomas, Mizrachi Aviram, Popovtzer Aron
Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, Petah Tikva, Israel.
Institute of Oncology, Davidoff Center, Rabin Medical Center, Petach Tikva, Israel.
Head Neck. 2025 Jul;47(7):1839-1847. doi: 10.1002/hed.28093. Epub 2025 Jan 31.
The role of post-operative radiotherapy (PORT) in early-stage (T1-T2N0M0) oral tongue squamous cell carcinoma (OTSCC) with minor adverse features (MAF) including perineural invasion (PNI) and poorly differentiated carcinoma (PDC) is not well described. We aimed to study the role of PORT among these patients.
A retrospective review of patients treated for early-stage OTSCC between 2000 and 2022 in a tertiary-care referral center while comparing patients treated by surgery and PORT with patients treated by surgery alone.
One hundred fifty-four patients were included and 36 (23.4%) received PORT. The PORT subgroup had a significantly higher rate of MAF. Survival rates were similar between the two sub-groups. PORT demonstrated a trend toward improved overall survival (odds ratio = 0.406, p = 0.07). Patients with PNI or PDC treated with PORT experienced improved survival rates.
PORT has an important role when treating early-stage OTSCC with MAF. It should be considered especially among patients with PNI or PDC.
术后放疗（PORT）在具有微小不良特征（MAF）的早期（T1-T2N0M0）口腔舌鳞状细胞癌（OTSCC）中的作用，这些微小不良特征包括神经周侵犯（PNI）和低分化癌（PDC），目前尚未得到充分描述。我们旨在研究PORT在这些患者中的作用。
对2000年至2022年在一家三级医疗转诊中心接受早期OTSCC治疗的患者进行回顾性研究，同时比较接受手术加PORT治疗的患者与仅接受手术治疗的患者。
纳入154例患者，其中36例（23.4%）接受了PORT。PORT亚组的MAF发生率显著更高。两个亚组的生存率相似。PORT显示出总体生存率改善的趋势（比值比=0.406，p=0.07）。接受PORT治疗的PNI或PDC患者生存率有所提高。
PORT在治疗具有MAF的早期OTSCC时具有重要作用。尤其在PNI或PDC患者中应考虑使用。
