Garbellotto Grasiane Izidorio, Reis Fernanda Jardim, Feoli Ana Maria Pandolfo, Piovesan Carla Haas, Gustavo Andréia da Silva, Oliveira Margareth da Silva, Macagnan Fabrício Edler, Ferreira Carlos Alexandre Sanchez, Bauer Moisés Evandro, Wietzycoski Cácio Ricardo
Faculty of Nursing, Nutrition and Physiotherapy, Pontifícia Universidade Católica do Rio Grande do Sul.
Post-graduate Programa in Molecular and Cellular Biology, Biosciences Faculty, PUCRS, Porto Alegre, RS, Brazil.
Arq Bras Cir Dig. 2018 Jun 21;31(1):e1351. doi: 10.1590/0102-672020180001e1351.
Actually the lifestyle exposes the population to several risk factors related to alimentary habits and less physical activity that contributes to chronic diseases appearance worldwide.
To analyze the association between salivary cortisol and the components of metabolic syndrome.
This is a cross-sectional study. As part of it, 28 individuals aged 30-59 years presenting three or more of the following findings: CA: ≥88 cm for women and ≥102 cm for men; SBP>130 mmHg and DBP>85 mmHg; GL>100 mg/dl; TG>150 mg/dl; HDL<40 mg/dl for men and <50 mg/dl for women. Was performed analysis of salivary cortisol (by radioimmunoassay) from 25 salivary samples collected throughout the day, for evaluating changes in the circadian rhythm of this hormone (8AM, noon and 8PM).
28 evaluated individuals had a mean age of 51.9±7.5 years, mostly women (64.3%) and a mean of BMI 33.6±3.2 kg/m². The cortisol level from the 8AM averaged 18.7±4.8 ng/dlL. Individuals with FPG>110mg/dl, have significantly lower average levels of cortisol than ones with FPG <110 (12.8±5,2 vs. 17.3±4.2). Significant correlations were HOMA vs. WC (r=0,465; p˂0,005) and TG (r=0,473; p˂0,005), WC vs. FG (r=0,446; p˂0,005) and BMI (r=0,730; p˂0.0001); TG vs. HDL (r=0,441 p˂0,005) and FG (r=0,440; p˂0,005).
Morning salivary cortisol in subjects with chronically elevated blood glucose can represent a downregulation of the hypothalamic-pituitary adrenal axis. This is an important finding not yet well investigated.
实际上，这种生活方式使人们面临多种与饮食习惯和较少体育活动相关的风险因素，而这些因素会导致全球范围内慢性病的出现。
分析唾液皮质醇与代谢综合征各组分之间的关联。
这是一项横断面研究。作为研究的一部分，选取了28名年龄在30至59岁之间的个体，他们呈现出以下三种或更多情况：腹围（CA）：女性≥88厘米，男性≥102厘米；收缩压（SBP）>130 mmHg且舒张压（DBP）>85 mmHg；血糖（GL）>100 mg/dl；甘油三酯（TG）>150 mg/dl；男性高密度脂蛋白（HDL）<40 mg/dl，女性<50 mg/dl。通过放射免疫分析法对全天收集的25份唾液样本进行唾液皮质醇分析，以评估该激素昼夜节律的变化（上午8点、中午和晚上8点）。
28名被评估个体的平均年龄为51.9±7.5岁，大多数为女性（64.3%），平均体重指数（BMI）为33.6±3.2 kg/m²。上午8点时的皮质醇水平平均为18.7±4.8 ng/dlL。空腹血糖（FPG）>110mg/dl的个体，其皮质醇平均水平显著低于FPG<110的个体（12.8±5.2 vs. 17.3±4.2）。稳态模型评估法（HOMA）与腹围（WC）（r = 0.465；p<0.005）和甘油三酯（TG）（r = 0.473；p<0.005）、WC与空腹血糖（FG）（r = 0.446；p<0.005）和BMI（r = 0.730；p<0.0001）、TG与HDL（r = 0.441，p<0.005）和FG（r = 0.440；p< 0.005）之间存在显著相关性。
血糖长期升高的受试者早晨唾液皮质醇水平可能代表下丘脑 - 垂体 - 肾上腺轴的下调。这是一个尚未得到充分研究的重要发现。
