Center for Social Epidemiology and Population Health, Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109, USA.
J Clin Endocrinol Metab. 2011 Nov;96(11):3483-92. doi: 10.1210/jc.2011-0483. Epub 2011 Aug 31.
Prior research has identified associations between social-environmental factors and metabolic syndrome (MetS) components. The physiological mechanisms underlying these associations are not fully understood, but alterations in activity of the hypothalamic-pituitary-adrenal axis, a stress-responsive biological system, have been hypothesized to play a role.
The aim of the study was to determine whether MetS diagnosis and specific clusters of MetS components (waist circumference, high-density lipoproteins, glucose, and blood pressure) are associated with cortisol levels.
We conducted cross-sectional analyses of data from the Multi-Ethnic Study of Atherosclerosis (MESA) study in the general community.
We studied a population-based sample of 726 adults (ages 48 to 89 yr) who do not have clinical diabetes.
INTERVENTION(S): There were no interventions.
MAIN OUTCOME MEASURE(S): Cortisol awakening response, cortisol decline across the waking day, and total cortisol output were analyzed (using 18 timed measures of salivary cortisol over 3 d).
Overall, we found little evidence that the presence of MetS or its components is related to cortisol output or patterns. Contrary to expectation, the presence of MetS was associated with lower rather than higher area under the curve, and no consistent pattern was observed when MetS components or subsets of components were examined in relation to cortisol.
Our findings do not support the hypothesis that differences in level or diurnal pattern of salivary cortisol output are associated with MetS among persons without clinical diabetes.
先前的研究已经确定了社会环境因素与代谢综合征（MetS）成分之间的关联。这些关联的生理机制尚不完全清楚，但假设下丘脑-垂体-肾上腺轴（一种应激反应性生物系统）的活性改变可能起作用。
本研究旨在确定 MetS 诊断和 MetS 成分（腰围、高密度脂蛋白、葡萄糖和血压）的特定聚类是否与皮质醇水平相关。
我们对一般社区中的动脉粥样硬化多民族研究（MESA）研究的数据进行了横断面分析。
我们研究了一个基于人群的 726 名成年人（年龄 48 至 89 岁）的样本，他们没有临床糖尿病。
没有干预措施。
分析皮质醇觉醒反应、清醒日皮质醇下降和总皮质醇输出（使用 3 天内 18 次唾液皮质醇时间测量）。
总体而言，我们几乎没有发现证据表明 MetS 或其成分的存在与皮质醇输出或模式有关。与预期相反，MetS 的存在与较低而不是较高的曲线下面积相关，当以 MetS 成分或其成分的子集与皮质醇相关时，没有观察到一致的模式。
我们的研究结果不支持这样的假设，即在没有临床糖尿病的人群中，唾液皮质醇输出的水平或昼夜模式的差异与 MetS 相关。
