代谢综合征的全面定义。
A comprehensive definition for metabolic syndrome.
作者信息
Huang Paul L
机构信息
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
出版信息
Dis Model Mech. 2009 May-Jun;2(5-6):231-7. doi: 10.1242/dmm.001180.
Abstract
The metabolic syndrome refers to the co-occurrence of several known cardiovascular risk factors, including insulin resistance, obesity, atherogenic dyslipidemia and hypertension. These conditions are interrelated and share underlying mediators, mechanisms and pathways. There has been recent controversy about its definition and its utility. In this article, I review the current definitions for the metabolic syndrome and why the concept is important. It identifies a subgroup of patients with shared pathophysiology who are at high risk of developing cardiovascular disease and type 2 diabetes. By considering the central features of the metabolic syndrome and how they are related, we may better understand the underlying pathophysiology and disease pathogenesis. A comprehensive definition for the metabolic syndrome and its key features would facilitate research into its causes and hopefully lead to new insights into pharmacologic and lifestyle treatment approaches.
摘要
代谢综合征是指几种已知的心血管危险因素同时出现，包括胰岛素抵抗、肥胖、致动脉粥样硬化血脂异常和高血压。这些情况相互关联，具有共同的潜在介质、机制和途径。最近关于其定义及其实用性存在争议。在本文中，我回顾了代谢综合征的当前定义以及该概念为何重要。它确定了一组具有共同病理生理学的患者亚组，这些患者患心血管疾病和2型糖尿病的风险很高。通过考虑代谢综合征的核心特征及其相互关系，我们可以更好地理解潜在的病理生理学和疾病发病机制。对代谢综合征及其关键特征的全面定义将有助于对其病因的研究，并有望带来对药物和生活方式治疗方法的新见解。
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