癌胚抗原水平在胃癌患者术中腹腔灌洗中的预后价值
PROGNOSTIC VALUE OF CARCINOEMBRYONIC ANTIGEN LEVELS IN TRANSOPERATIVE PERITONEAL LAVAGE IN PATIENTS WITH GASTRIC CANCER.
作者信息
Alves Letícia Biscaino, Tsukazan Maria Teresa, Serafim Ana Elisa, Mendoza Rolando, Padoin Alexandre Vontobel, Baú Plínio Carlos, Moreira Luis Fernando
机构信息
Post-Graduate Program in Surgery, Hospital de Clínicas of Porto Alegre, Federal University of Rio Grande do Sul.
Center for Obesity and Metabolic Syndrome, São Lucas Hospital, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS).
出版信息
Arq Bras Cir Dig. 2018 Jun 21;31(1):e1358. doi: 10.1590/0102-672020180001e1358.
BACKGROUND
The carcinoembryonic antigen level in peritoneal lavage has been showing to be a reliable prognostic factor in gastric cancer.
AIM
To identify any association between carcinoembryonic antigen level in peritoneal lavage, in gastric cancer patients, with mortality, peritoneal recurrence, tumor relapse or other prognostic factors.
METHODS
In total, 30 patients (22 men, 8 women; median age 66 years) with resectable gastric cancer (mainly stage III and IV) were studied. Carcinoembryonic antigen level in peritoneal lavage was detected at operation by immunocytochemical method and a level over 210 ng/g of protein was considered as positive.
RESULTS
There were detected 10 positive cases (33.3%) of plCEA levels. These levels were associated with mortality, RR: 2.1 (p=0.018); peritoneal recurrence, OR: 9.0 (p=0.015); and relapse or gastric cancer progression, OR: 27.0 (p=0.001).
CONCLUSION
Increased levels of plCEA fairly predicts mortality, peritoneal recurrence tumor relapse or cancer progression.
背景
已证明胃癌患者腹腔灌洗中的癌胚抗原水平是一个可靠的预后因素。
目的
确定胃癌患者腹腔灌洗中癌胚抗原水平与死亡率、腹膜复发、肿瘤复发或其他预后因素之间是否存在关联。
方法
共研究了30例可切除胃癌患者（22例男性，8例女性；中位年龄66岁），主要为III期和IV期。术中采用免疫细胞化学方法检测腹腔灌洗中的癌胚抗原水平，蛋白水平超过210 ng/g被视为阳性。
结果
检测到10例（33.3%）腹腔灌洗癌胚抗原水平阳性病例。这些水平与死亡率相关，相对危险度：2.1（p=0.018）；腹膜复发，比值比：9.0（p=0.015）；以及复发或胃癌进展，比值比：27.0（p=0.001）。
结论
腹腔灌洗癌胚抗原水平升高能较好地预测死亡率、腹膜复发、肿瘤复发或癌症进展。
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