Asao T, Fukuda T, Yazawa S, Nagamachi Y
First Department of Surgery, Gunma University School of Medicine, Maebashi, Japan.
Cancer. 1991 Jul 1;68(1):44-7. doi: 10.1002/1097-0142(19910701)68:1<44::aid-cncr2820680109>3.0.co;2-j.
Carcinoembryonic antigen (CEA) levels were determined in the peritoneal washings from 120 patients with gastric cancer and 9 patients with benign diseases. Elevated values (greater than 100 ng/g of protein) were observed in 20 of 25 patients with gastric cancer with visible dissemination and 16 of 25 patients with serosal invasion but no dissemination. The same elevation was found in only 9 of 70 patients with no serosal invasion and none of the patients with benign disease. The 2-year survival rates after curative operation for the patients with and without elevation of CEA levels were 21% (19 patients) and 100% (66 patients), respectively (P less than 0.001). A negative correlation was found between CEA levels and survival times after noncurative operation. These results indicate that the CEA level in peritoneal washings could be a sensitive detector of invisible peritoneal dissemination and a new predictor for the postoperative prognosis of gastric cancer.
对120例胃癌患者和9例良性疾病患者的腹腔冲洗液进行癌胚抗原（CEA）水平测定。在25例有可见播散的胃癌患者中有20例、25例有浆膜侵犯但无播散的患者中有16例CEA值升高（大于100 ng/g蛋白质）。在70例无浆膜侵犯的患者中只有9例出现同样程度的升高，而良性疾病患者中无一例升高。CEA水平升高和未升高的患者根治性手术后的2年生存率分别为21%（19例）和100%（66例）（P<0.001）。在非根治性手术后，CEA水平与生存时间呈负相关。这些结果表明，腹腔冲洗液中的CEA水平可能是隐匿性腹膜播散的敏感检测指标，也是胃癌术后预后的新预测指标。
