Rappaport A, Sturtz F, Guicheney P
Brain Res. 1985 Sep 30;344(1):158-61. doi: 10.1016/0006-8993(85)91202-8.
Alpha 1- and alpha 2-adrenoceptors were assessed by binding studies using [3H]prazosin and [3H]p-aminoclonidine as ligands in membrane preparations from the cortex, hippocampus and hypothalamus of rats, 3 weeks after intracerebroventricular injection of the neurotoxin 5,7-dihydroxytryptamine. Cortical alpha 1 and hippocampal alpha 2 adrenoceptors were significantly increased. Treatment also affected the affinity of cortical alpha 2 adrenoceptors. These results suggest a heterologous, region-specific regulation of both subtypes of central alpha-adrenergic receptors by serotonin.
在向大鼠脑室内注射神经毒素5,7-二羟基色胺3周后，利用[3H]哌唑嗪和[3H]对氨基可乐定作为配体，通过结合研究评估了大鼠皮质、海马和下丘脑膜制剂中的α1和α2肾上腺素能受体。皮质α1和海马α2肾上腺素能受体显著增加。该处理还影响了皮质α2肾上腺素能受体的亲和力。这些结果表明，5-羟色胺对中枢α-肾上腺素能受体的两种亚型具有异源性、区域特异性调节作用。
