Lynch M, Littleton J, McKernan R M, Durcan M J, McMillan T, Campbell I C
Brain Res. 1983 Dec 12;288(1-2):145-9. doi: 10.1016/0006-8993(83)90088-4.
Alpha-Adrenoceptor number and function were assessed in rat cortex after ethanol and immobilization stress. Rats subjected to immobilization stress for 2 h/day/7 days showed a significant reduction in alpha 2-adrenoceptors in cortex ( [3H]clonidine binding) but no change in alpha 1-adrenoceptors ( [3H]prazosin binding). The inhibitory effect of clonidine (500 nM) on 3H efflux from cortical slices preincubated with [3H]norepinephrine was reversed in the stressed animals. These effects on alpha 2-adrenoceptor number and function were reduced when stress was accompanied by chronic administration of ethanol (35% of calories in a liquid diet) although when given alone ethanol produced small changes in the same direction as those produced by stress. It is suggested that, in its effects on cortical alpha-adrenoceptors, chronic ethanol administration attenuates the effects of severe stress though itself perhaps acting as a mild stressor when given as part of a liquid diet regimen.
在乙醇和固定应激后，对大鼠皮质中的α-肾上腺素能受体数量和功能进行了评估。每天固定应激2小时、持续7天的大鼠，其皮质中的α2-肾上腺素能受体（[3H]可乐定结合）显著减少，但α1-肾上腺素能受体（[3H]哌唑嗪结合）没有变化。在应激动物中，可乐定（500 nM）对用[3H]去甲肾上腺素预孵育的皮质切片中3H流出的抑制作用被逆转。当应激伴有慢性给予乙醇（液体饮食中热量的35%）时，这些对α2-肾上腺素能受体数量和功能的影响会减弱，尽管单独给予乙醇时也会产生与应激相同方向的微小变化。研究表明，在对皮质α-肾上腺素能受体的影响方面，慢性给予乙醇会减弱严重应激的影响，尽管当作为液体饮食方案的一部分给予时，乙醇本身可能作为一种轻度应激源起作用。
