Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, 650118, China.
Yunnan Key Laboratory of Vaccine Research and Development of Severe Infectious Disease, Kunming, 650118, China.
Arch Virol. 2018 Oct;163(10):2903-2906. doi: 10.1007/s00705-018-3906-7. Epub 2018 Jun 14.
The epidemic of dengue virus infections has spread markedly in Yunnan province of China in recent years due to an increase in the number of imported dengue cases. To the best of our knowledge, the present study is the first to report a whole genome sequence and molecular characterization of an imported DENV-4 isolate from Thailand. The current strain, 2013JH285, has an RNA genome of 10,772 nucleotides that shares 99.0% nucleotide and 99.7% amino acid sequence identity with the 2013 Thailand strain CTI2-13. Phylogenetic analysis of the whole genome sequence revealed that the 2013JH285 strain belongs to genotype I of DENV-4. Recombination analysis suggested that the 2013JH285 strain originated from inter-genotypic recombination of DENV-4 strains. The new complete DENV-4 genome sequence reported here might contribute to further understanding of the molecular epidemiology and disease surveillance of DENV-4 in China.
近年来，由于输入性登革热病例的增加，中国云南省的登革热病毒感染疫情明显蔓延。据我们所知，本研究首次报告了从泰国输入的 DENV-4 分离株的全基因组序列和分子特征。当前的菌株 2013JH285 具有 10772 个核苷酸的 RNA 基因组，与 2013 年泰国株 CTI2-13 共享 99.0%的核苷酸和 99.7%的氨基酸序列同一性。全基因组序列的系统进化分析表明，2013JH285 株属于 DENV-4 的基因型 I。重组分析表明，2013JH285 株起源于 DENV-4 株的基因型间重组。本报告的新的完整 DENV-4 基因组序列可能有助于进一步了解中国 DENV-4 的分子流行病学和疾病监测。
