NYU Winthrop Hospital, Mineola, NY, USA.
The Cura Foundation, New York, NY, USA.
Cardiovasc Drugs Ther. 2018 Dec;32(6):611-616. doi: 10.1007/s10557-018-6798-6.
Cardiovascular disease is the leading cause of death in men and women in the USA. Once a patient experiences an acute coronary syndrome (ACS), they are at increased risk for hospital readmission within 30 days and 6 months after discharge and more importantly, they have worse survival. Hospital readmissions lead to poor clinical outcomes for the patient and also significantly increase healthcare costs due to repeat diagnostic evaluation, imaging, and coronary interventions. The goal after hospital discharge is to modify cardiovascular (CV) risk factors including hypertension, hyperlipidemia, and diabetes to prevent repeat coronary events; however, drug therapy is only one aspect. Several diets have been shown to decrease weight and reduce these risk factors over short durations; however, most people typically cannot sustain their diet and regain the weight. The Intelligent Quisine (IQ) diet is a prepared meal plan that was designed to meet the American Heart Association and American Diabetes Association nutritional guidelines and simplify the daily consumption of a nutritionally complete, calorie conscious meal. The IQ diet has been shown to significantly reduce blood pressure, cholesterol levels, glucose levels, and weight over a 10-week period. Additional studies have shown that patients are able to remain compliant on the diet for a year and maintain the reduction of their CV risk factors. If patients are consistent with a healthy calorie conscious and nutritionally complete diet modifying CV risk factors long term, then food could be as powerful in reducing CV events as evidence-based drug therapy. There is a need to begin conceptualizing food as medicine. To this end, it is time for a randomized control trial implementing the IQ diet versus current standard dietary recommendations in a large number of patients and measuring hard CV endpoints. Many readmissions can be avoided with proper patient education and support emphasizing lifestyle modifications such as eating healthy and smoking cessation on a foundation of optimal medical therapy.
心血管疾病是美国男性和女性的主要死因。一旦患者经历急性冠状动脉综合征 (ACS),他们在出院后 30 天和 6 个月内再次住院的风险增加,更重要的是,他们的生存率更差。再次住院会导致患者的临床结局不佳,并且由于重复的诊断评估、影像学检查和冠状动脉介入治疗,也会显著增加医疗保健成本。出院后的目标是调整心血管 (CV) 危险因素,包括高血压、高血脂和糖尿病,以预防再次发生冠状动脉事件;然而,药物治疗只是其中的一个方面。有几种饮食已被证明可以在短时间内减轻体重并降低这些危险因素;然而,大多数人通常无法维持他们的饮食并恢复体重。智能烹饪 (IQ) 饮食是一种预制餐计划,旨在满足美国心脏协会和美国糖尿病协会的营养指南,并简化每日食用营养全面、热量意识的膳食。IQ 饮食已被证明可在 10 周内显著降低血压、胆固醇水平、血糖水平和体重。此外的研究表明,患者能够在一年内遵守饮食计划并维持 CV 危险因素的降低。如果患者坚持健康的热量意识和营养全面的饮食来长期调整 CV 危险因素,那么食物在降低 CV 事件方面的作用可能与循证药物治疗一样强大。我们需要开始将食物视为药物。为此,是时候在大量患者中实施 IQ 饮食与当前标准饮食建议的随机对照试验,并测量硬性 CV 终点了。通过适当的患者教育和支持,强调生活方式的改变,如健康饮食和戒烟,可以避免许多再次住院的情况,而生活方式的改变是基于最佳的医疗治疗。