Bluhm R E, Molnar J, Cohen M M
Clin Neuropharmacol. 1985;8(3):280-5. doi: 10.1097/00002826-198509000-00009.
Pentoxifylline decreases the cerebral edema resulting from cortical freezing lesions in cats, produces mitochondrial hypertrophy with preservation of structure in gerbils, and increases survival rate in gerbils rendered ischemic by temporary bilateral carotid occlusion. Since all these findings may be related to energy metabolism, the effect of the drug on postischemic cerebral phosphocreatine and ATP concentrations and on cytochrome oxidase activity has been studied. Brain slices prepared from animals subjected to bilateral carotid occlusion for 30 min and treated with pentoxifylline at release of occlusion, then allowed 3 h for recovery, exhibited higher concentrations of ATP and higher levels of cytochrome oxidase activity than did those of the untreated animals.
己酮可可碱可减轻猫因皮层冷冻损伤所致的脑水肿，使沙鼠出现线粒体肥大且结构保持完整，并提高因双侧颈总动脉暂时闭塞而导致缺血的沙鼠的存活率。由于所有这些发现可能都与能量代谢有关，因此已对该药物对缺血后脑磷酸肌酸和三磷酸腺苷（ATP）浓度以及细胞色素氧化酶活性的影响进行了研究。从经历双侧颈总动脉闭塞30分钟并在闭塞解除时用己酮可可碱治疗的动物制备脑切片，然后让其恢复3小时，这些脑切片显示出比未治疗动物更高的ATP浓度和更高水平的细胞色素氧化酶活性。
