Hartmann J F, Becker R A, Cohen M M
Neurology. 1977 Jan;27(1):77-84. doi: 10.1212/wnl.27.1.77.
Normal gerbils and those made ischemic for 15 to 60 minutes by bilateral common carotid artery occlusion were studied ultrastructurally after administration of the vasoactive drug pentoxifylline. In both groups, hypertrophy of neuronal mitochondria was found in the hippocampus and cerebral cortex. Planimetry of electron micrographs revealed a statistically significant increase in average mitochondrial size of drug-treated animals compared with untreated ischemic gerbils and normal controls; the treated ischemic group showed the greatest increase. Incubated cortical slices from normal gerbils that were given the drug 5 hours before they were killed showed a significant increase in oxygen consumption compared with controls.
对正常沙鼠以及通过双侧颈总动脉闭塞使其缺血15至60分钟的沙鼠，在给予血管活性药物己酮可可碱后进行了超微结构研究。在两组中，均发现海马体和大脑皮层中神经元线粒体肥大。电子显微镜照片的平面测量显示，与未治疗的缺血沙鼠和正常对照组相比，药物治疗动物的线粒体平均大小有统计学意义的增加；治疗的缺血组增加最为明显。在处死前5小时给予该药物的正常沙鼠的离体皮质切片，与对照组相比，耗氧量显著增加。
