铜绿假单胞菌中铁的获取与生物膜形成的相互依赖性。
Interdependence between iron acquisition and biofilm formation in Pseudomonas aeruginosa.
机构信息
Department of Biosciences, Rice University, Houston, USA.
出版信息
J Microbiol. 2018 Jul;56(7):449-457. doi: 10.1007/s12275-018-8114-3. Epub 2018 Jun 14.
Abstract
Bacterial biofilms remain a persistent threat to human healthcare due to their role in the development of antimicrobial resistance. To combat multi-drug resistant pathogens, it is crucial to enhance our understanding of not only the regulation of biofilm formation, but also its contribution to bacterial virulence. Iron acquisition lies at the crux of these two subjects. In this review, we discuss the role of iron acquisition in biofilm formation and how hosts impede this mechanism to defend against pathogens. We also discuss recent findings that suggest that biofilm formation can also have the reciprocal effect, influencing siderophore production and iron sequestration.
摘要
由于其在抗生素耐药性发展中的作用，细菌生物膜仍然是人类健康护理的持续威胁。为了对抗多药耐药病原体，不仅要增强我们对生物膜形成的调控的理解，还要增强我们对其对细菌毒力贡献的理解，这一点至关重要。铁的获取是这两个主题的关键。在这篇综述中，我们讨论了铁获取在生物膜形成中的作用，以及宿主如何阻止这种机制来抵御病原体。我们还讨论了最近的发现，表明生物膜形成也可以产生相反的效果，影响铁载体的产生和铁的螯合。
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