Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Biochemistry. 2024 Aug 6;63(15):1877-1891. doi: 10.1021/acs.biochem.4c00276. Epub 2024 Jul 23.
Siderophores are metal-binding secondary metabolites that assist in iron homeostasis and have been of interest to the scientific community for the last half century. Foundational siderophore research has enabled several translational applications including siderophore-antibiotic and siderophore-peptide conjugates, identification of new antimicrobial targets, advances in disease imaging, and novel therapeutics. This review aims to connect the basic science research (biosynthesis, cellular uptake, gene regulation, and effects on homeostasis) of well-known siderophores with the successive translational application that results. Intertwined throughout are connections to the career of Christopher T. Walsh, his impact on the field of chemical biology, and the legacy of his trainees who continue to innovate.
铁载体是一种结合金属的次级代谢产物，有助于铁的动态平衡，在过去半个世纪一直受到科学界的关注。基础铁载体研究促成了一些转化应用，包括铁载体-抗生素和铁载体-肽缀合物、新抗菌靶点的鉴定、疾病成像的进步和新型疗法。本综述旨在将著名铁载体的基础科学研究（生物合成、细胞摄取、基因调控和对动态平衡的影响）与随后的转化应用联系起来。贯穿始终的是与克里斯托弗·T·沃尔什（Christopher T. Walsh）的职业生涯的联系，他对化学生物学领域的影响，以及他的继续创新的受训者的遗产。
