Doris Mhairi K, Otaki Yuka, Krishnan Sandeep K, Kwiecinski Jacek, Rubeaux Mathieu, Alessio Adam, Pan Tinsu, Cadet Sebastien, Dey Damini, Dweck Marc R, Newby David E, Berman Daniel S, Slomka Piotr J
BHF Centre for Cardiovascular Science, Clinical Research Imaging Centre, Edinburgh Heart Centre, University of Edinburgh, 49 Little France Crescent, Edinburgh, Scotland, EH16 4SB, UK.
Department of Imaging and Medicine and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
J Nucl Cardiol. 2020 Apr;27(2):494-504. doi: 10.1007/s12350-018-1317-5. Epub 2018 Jun 11.
Coronary PET shows promise in the detection of high-risk atherosclerosis, but there remains a need to optimize imaging and reconstruction techniques. We investigated the impact of reconstruction parameters and cardiac motion-correction in F Sodium Fluoride (F-NaF) PET.
Twenty-two patients underwent F-NaF PET within 22 days of an acute coronary syndrome. Optimal reconstruction parameters were determined in a subgroup of six patients. Motion-correction was performed on ECG-gated data of all patients with optimal reconstruction. Tracer uptake was quantified in culprit and reference lesions by computing signal-to-noise ratio (SNR) in diastolic, summed, and motion-corrected images.
Reconstruction using 24 subsets, 4 iterations, point-spread-function modelling, time of flight, and 5-mm post-filtering provided the highest median SNR (31.5) compared to 4 iterations 0-mm (22.5), 8 iterations 0-mm (21.1), and 8 iterations 5-mm (25.6; all P < .05). Motion-correction improved SNR of culprit lesions (n = 33) (24.5[19.9-31.5]) compared to diastolic (15.7[12.4-18.1]; P < .001) and summed data (22.1[18.9-29.2]; P < .001). Motion-correction increased the SNR difference between culprit and reference lesions (10.9[6.3-12.6]) compared to diastolic (6.2[3.6-10.3]; P = .001) and summed data (7.1 [4.8-11.6]; P = .001).
The number of iterations and extent of post-filtering has marked effects on coronary F-NaF PET quantification. Cardiac motion-correction improves discrimination between culprit and reference lesions.
冠状动脉正电子发射断层显像（PET）在检测高危动脉粥样硬化方面显示出前景，但仍需要优化成像和重建技术。我们研究了重建参数和心脏运动校正对氟[¹⁸F]氟化钠（F-NaF）PET的影响。
22例患者在急性冠状动脉综合征发作后22天内接受了F-NaF PET检查。在6例患者的亚组中确定了最佳重建参数。对所有采用最佳重建的患者的心电图门控数据进行运动校正。通过计算舒张期、总合期和运动校正图像中的信噪比（SNR），对罪犯病变和对照病变的示踪剂摄取进行定量分析。
与4次迭代0毫米（22.5）、8次迭代0毫米（21.1）和8次迭代5毫米（25.6；所有P < 0.05）相比，使用24个子集、4次迭代、点扩散函数建模、飞行时间和5毫米后置滤波进行重建可提供最高的中位数SNR（31.5）。与舒张期（15.7[12.4 - 18.1]；P < 0.001）和总合期数据（22.1[18.9 - 29.2]；P < 0.001）相比，运动校正提高了罪犯病变（n = 33）的SNR（24.5[19.9 - 31.5]）。与舒张期（6.2[3.6 - 10.3]；P = 0.001）和总合期数据（7.1[4.8 - 11.6]；P = 0.001）相比，运动校正增加了罪犯病变和对照病变之间的SNR差异（10.9[6.3 - 12.6]）。
迭代次数和后置滤波程度对冠状动脉F-NaF PET定量分析有显著影响。心脏运动校正可改善罪犯病变和对照病变之间的辨别能力。
