Department of Anesthesiology, Xuzhou Children's Hospital, Xuzhou, Jiangsu, P.R. China.
Eur Rev Med Pharmacol Sci. 2018 Jun;22(12):3971-3975. doi: 10.26355/eurrev_201806_15281.
To investigate the effect of sevoflurane on cognitive function and inflammatory response of children after general anesthesia at different times.
Ninety-three pediatric patients who underwent general anesthesia surgery were enrolled and divided into groups based on time under general anesthesia: group A (<1 h, n=27), group B (1-3 h, n=36), and group C (≥ 3 h, n=30). Changes in cognitive function and serum inflammatory index were compared.
The occurrence of postoperative cognitive dysfunction (POCD) in group A and B was lower than in group C and the difference was statistically significant (p<0.05). The levels of caspase-3, TNF-α, and IL-6 in the POCD group at the different time points were significantly higher than in the non-POCD group and the differences were statistically significant (p<0.05). Caspase-3, TNF-α, and IL-6 levels in the POCD group at the different time points significantly changed and were highest during the recovery period, while there were no significant changes in the non-POCD group at the different time points.
The prolonged sevoflurane inhalational anesthesia time (≥ 3 h) enhanced the occurrence of POCD and was related to the expression levels of serum caspase-3, TNF-α, and IL-6.
探讨不同时间点七氟醚全身麻醉对儿童认知功能及炎症反应的影响。
选择全麻手术患儿 93 例，根据全麻时间分为 A 组（<1 h，n=27）、B 组（1~3 h，n=36）和 C 组（≥3 h，n=30）。比较认知功能和血清炎症指标的变化。
A 组和 B 组术后认知功能障碍（POCD）发生率低于 C 组，差异有统计学意义（p<0.05）。不同时间点 POCD 组 caspase-3、TNF-α、IL-6 水平明显高于非 POCD 组，差异有统计学意义（p<0.05）。不同时间点 POCD 组 caspase-3、TNF-α、IL-6 水平明显变化，恢复期最高，而非 POCD 组各时间点均无明显变化。
长时间七氟醚吸入麻醉（≥3 h）可增加 POCD 的发生，与血清 caspase-3、TNF-α、IL-6 的表达水平有关。
