Oh Kwan Young, Jin Chan Hee, Sohn Young Hak, Cho Hyun A, Ki Moran
Clin Exp Obstet Gynecol. 2017;44(3):429-433.
To investigate the prevalence of abnormal vaginal flora (AVF) and predictive factors for intrauterine infection in pregnant Korean women with preterm labor.
The authors reviewed the medical records of 106 pregnant Korean women with preterm labor admitted to Eulji Medical Center between January 2006 and August 2011. The results of vaginal discharge tests and maternal serum C-reactive protein (CRP) level at admission, placental biopsy, and perinatal outcomes were searched. The prevalence of abnormal vaginal flora was calculated. The perinatal outcomes and predictive factors for intrauterine infections were analyzed based on placental pathology and early-onset neonatal sepsis.
The prevalence of abnormal vaginal flora was 75.4%. Ureaplasma urealyticunz (UU), intermediate flora, Candidiasis, bacterial vaginosis, and aerobic bacterial colonization were detected in 40.6%, 38.7%, 17%, 14.2%, and 11.3% of the women, respectively. The frequency of early-onset neonatal sepsis was significantly different between women with aerobic bacterial colonization and those with normal flora (p = 0.008). An elevated maternal serum CRP level was an independent intrauterine infection predictor (odds ratio, 1.918; 95% confidence interval, 1.102-3.338; p = 0.048).
Aerobic bacterial colonization may predict early-onset neonatal sepsis. An elevated maternal serum CRP level was an independent intrauterine infection predictor based on placental infections and early-onset neonatal sepsis.
探讨早产韩国孕妇阴道菌群异常（AVF）的患病率及宫内感染的预测因素。
作者回顾了2006年1月至2011年8月入住乙支医学中心的106例早产韩国孕妇的病历。检索入院时阴道分泌物检查结果、母体血清C反应蛋白（CRP）水平、胎盘活检及围产期结局。计算阴道菌群异常的患病率。根据胎盘病理和早发型新生儿败血症分析围产期结局及宫内感染的预测因素。
阴道菌群异常的患病率为75.4%。分别在40.6%、38.7%、17%、14.2%和11.3%的女性中检测到解脲脲原体（UU）、中间型菌群、念珠菌病、细菌性阴道病和需氧菌定植。需氧菌定植的女性与正常菌群的女性相比，早发型新生儿败血症的发生率有显著差异（p = 0.008）。母体血清CRP水平升高是宫内感染的独立预测因素（比值比，1.918；95%置信区间，1.102 - 3.338；p = 0.048）。
需氧菌定植可能预测早发型新生儿败血症。基于胎盘感染和早发型新生儿败血症，母体血清CRP水平升高是宫内感染的独立预测因素。
