Nanobiotechnology Research Centre, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Nanomedicine (Lond). 2018 Jun;13(11):1319-1331. doi: 10.2217/nnm-2017-0385.
Nanoethosomal formulation containing silver sulfadiazine (SSD) was used to reduce bacterial burden and healing time in burn injuries.
MATERIALS & METHODS: Ethosomal formulations were characterized for their size, ζ-potential, morphology, drug encapsulation efficiency and in vitro release kinetics of SSD.
The optimized nanoethosomal suspension with a size of 206.7 ± 1.18, and ζ-potential value of -67.3 ± 0.45 mV exhibited a high SSD encapsulation efficiency (92.03 ± 0.79%). Results of antimicrobial tests indicated SSD-loaded ethosome formulation led to a significant reduction of colony number. Histopathological results demonstrated a wound contraction rate of 96.83% for the group treated with SSD ethosomal gel while untreated group showed 59.41%.
The SSD ethogels promotes the therapeutic effect of SSD for burn treatment.
载银磺胺嘧啶（SSD）纳米醇质体制剂被用于减少烧伤感染中的细菌负荷和愈合时间。
对醇质体制剂的粒径、ζ-电位、形态、SSD 包封率和体外释放动力学进行了表征。
优化后的纳米醇质体混悬剂粒径为 206.7±1.18nm，ζ-电位值为-67.3±0.45mV，SSD 包封率高达 92.03±0.79%。抗菌试验结果表明，载 SSD 的醇质体制剂可显著减少菌落数量。组织病理学结果表明，SSD 醇质体凝胶治疗组的创面收缩率为 96.83%，而未治疗组为 59.41%。
SSD 醇质体凝胶促进了 SSD 治疗烧伤的疗效。
