银磺胺嘧啶纳米水凝胶治疗烧伤：特性及体内效应研究。
Silver sulfadiazine nanoethogel for burn healing: characterization and investigation of its in vivo effects.
机构信息
Nanobiotechnology Research Centre, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Nanomedicine (Lond). 2018 Jun;13(11):1319-1331. doi: 10.2217/nnm-2017-0385.
AIM
Nanoethosomal formulation containing silver sulfadiazine (SSD) was used to reduce bacterial burden and healing time in burn injuries.
MATERIALS & METHODS: Ethosomal formulations were characterized for their size, ζ-potential, morphology, drug encapsulation efficiency and in vitro release kinetics of SSD.
RESULTS
The optimized nanoethosomal suspension with a size of 206.7 ± 1.18, and ζ-potential value of -67.3 ± 0.45 mV exhibited a high SSD encapsulation efficiency (92.03 ± 0.79%). Results of antimicrobial tests indicated SSD-loaded ethosome formulation led to a significant reduction of colony number. Histopathological results demonstrated a wound contraction rate of 96.83% for the group treated with SSD ethosomal gel while untreated group showed 59.41%.
CONCLUSION
The SSD ethogels promotes the therapeutic effect of SSD for burn treatment.
目的
载银磺胺嘧啶（SSD）纳米醇质体制剂被用于减少烧伤感染中的细菌负荷和愈合时间。
材料与方法
对醇质体制剂的粒径、ζ-电位、形态、SSD 包封率和体外释放动力学进行了表征。
结果
优化后的纳米醇质体混悬剂粒径为 206.7±1.18nm，ζ-电位值为-67.3±0.45mV，SSD 包封率高达 92.03±0.79%。抗菌试验结果表明，载 SSD 的醇质体制剂可显著减少菌落数量。组织病理学结果表明，SSD 醇质体凝胶治疗组的创面收缩率为 96.83%，而未治疗组为 59.41%。
结论
SSD 醇质体凝胶促进了 SSD 治疗烧伤的疗效。
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