School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, SE1 9NH, UK.
Nanomedicine (Lond). 2018 Jun;13(11):1255-1265. doi: 10.2217/nnm-2018-0029.
To explore the potential of albumin nanoparticles for oral drug delivery.
Sub-150 nm human serum albumin nanoparticles were fabricated via a desolvation technique. Nanoparticle cell uptake and epithelial translocation were tested in Caco-2 monolayers, while comparing with albumin solution.
Data suggest epithelial transcytosis of albumin, applied in solution form, via neonatal Fc receptor. Cell uptake of albumin nanoparticles demonstrated behaviors indicating a different cell uptake pathway compared with albumin solution. Importantly, application of equivalent concentrations of albumin solution or nanoparticles resulted in higher epithelial transport capacity of the latter, suggesting improvement of intestinal delivery via nanoformulation.
This study highlights for the first time that simply fabricated, nontoxic human serum albumin nanoparticles may find application in oral drug delivery.
探索白蛋白纳米粒用于口服药物递送的潜力。
通过去溶剂化技术制备亚 150nm 的人血清白蛋白纳米粒。通过与白蛋白溶液进行比较，在 Caco-2 单层细胞中测试纳米粒的细胞摄取和上皮转运。
数据表明，以溶液形式应用的白蛋白通过新生 Fc 受体进行上皮转胞吞。与白蛋白溶液相比，白蛋白纳米粒的细胞摄取表现出不同的细胞摄取途径。重要的是，应用相同浓度的白蛋白溶液或纳米粒会导致后者的上皮转运能力更高，这表明通过纳米制剂可改善肠道递药。
本研究首次强调，简单制备的、无毒的人血清白蛋白纳米粒可能在口服药物递送上具有应用前景。
