Martinsson A, Larsson K, Hjemdahl P
Chest. 1985 Oct;88(4):594-600. doi: 10.1378/chest.88.4.594.
Beta-adrenoceptor responsiveness was studied both in vivo and in vitro in patients with exercise-induced asthma (EIA), asthmatic patients without EIA (NEIA), and control subjects. All subjects were age- and sex-matched and without medication at least one week prior to the tests. In vivo, beta-adrenoceptor responsiveness was evaluated by plasma concentration-effect studies for intravenously infused isoprenaline (0.02-0.1 micrograms X kg-1 X min-1). Mainly beta 2-adrenoceptor mediated responses to isoprenaline, ie, decreases in diastolic blood pressure and increases in plasma cyclic AMP, were reduced in EIA patients but not in NEIA patients. Heart rate and plasma glycerol responses to isoprenaline did not differ between the groups. In vitro, the beta 2-adrenoceptor mediated accumulation of cyclic AMP in lymphocytes stimulated by isoprenaline was attenuated (p less than 0.05) in EIA patients, whereas the beta 2-adrenoceptor responsiveness of lymphocytes from NEIA patients was normal. Thus, beta 2-adrenoceptor mediated responses were reduced both in vivo and in vitro in EIA patients, but not in NEIA patients. This finding that beta 2-adrenoceptor responsiveness was reduced only in a subgroup of asthmatic patients could explain some of the controversies in the literature concerning beta-adrenoceptor function in asthma.
对运动诱发性哮喘（EIA）患者、无运动诱发性哮喘的哮喘患者（NEIA）和对照受试者进行了体内和体外β-肾上腺素能受体反应性研究。所有受试者在年龄和性别上匹配，且在测试前至少一周未服用药物。在体内，通过静脉输注异丙肾上腺素（0.02 - 0.1微克×千克⁻¹×分钟⁻¹）的血浆浓度-效应研究来评估β-肾上腺素能受体反应性。主要由β₂-肾上腺素能受体介导的对异丙肾上腺素的反应，即舒张压降低和血浆环磷酸腺苷增加，在EIA患者中降低，但在NEIA患者中未降低。各组间对异丙肾上腺素的心率和血浆甘油反应无差异。在体外，EIA患者中异丙肾上腺素刺激的淋巴细胞中环磷酸腺苷的β₂-肾上腺素能受体介导的积累减弱（p < 0.05），而NEIA患者淋巴细胞的β₂-肾上腺素能受体反应性正常。因此，β₂-肾上腺素能受体介导的反应在EIA患者体内和体外均降低，但在NEIA患者中未降低。这一发现即β₂-肾上腺素能受体反应性仅在一部分哮喘患者中降低，可能解释了文献中关于哮喘中β-肾上腺素能受体功能的一些争议。
