Larsson K, Hjemdahl P, Martinsson A
Chest. 1982 Nov;82(5):560-7. doi: 10.1378/chest.82.5.560.
The possibility that sympathoadrenal activity is altered in asthma was examined in eight patients with a history of exercise-induced asthma (EIA), eight matched patients with nonexercise induced asthma (NEIA), and eight matched healthy control subjects. No medication was allowed for at least one week before examination. In a pretrial exercise test diagnosis of EIA was confirmed and each individual's work capacity (Vo2 max) was determined. The trial consisted of an orthostatic test and a standardized exercise test at 80 to 90 percent of VO2 max on a treadmill. The trial exercise test caused a decrease in FEV1 in EIA patients only, whereas measurements of Sgaw revealed a significant but less pronounced postexercise bronchoconstriction in NEIA-patients as well. Basal plasma catecholamine levels were similar in all groups. Noradrenaline and adrenaline levels were approximately doubled by the orthostatic test and increased approximately ten-fold following exercise, with no differences between the groups. Plasma cAMP levels were approximately doubled by the exercise test. In the EIA patients there was an inverse correlation between increases in plasma cAMP and decreases in Sgaw. Our study does not support earlier claims that exaggerated catecholamine response to exercise causes postexercise bronchoconstriction by alpha-adrenoceptor stimulation in EIA. Differences in study results appear to have methodologic explanations.
对8例有运动诱发性哮喘（EIA）病史的患者、8例匹配的非运动诱发性哮喘（NEIA）患者和8例匹配的健康对照者进行了研究，以探讨哮喘患者交感肾上腺活动是否改变。检查前至少一周内不允许使用任何药物。在预试验运动测试中确诊EIA，并测定每个人的工作能力（最大摄氧量）。试验包括直立试验和在跑步机上以最大摄氧量的80%至90%进行的标准化运动试验。试验运动测试仅导致EIA患者的第一秒用力呼气量（FEV1）下降，而气道传导率（Sgaw）测量显示，NEIA患者运动后也出现了显著但不太明显的支气管收缩。所有组的基础血浆儿茶酚胺水平相似。直立试验使去甲肾上腺素和肾上腺素水平增加约一倍，运动后增加约十倍，各组之间无差异。运动试验使血浆环磷酸腺苷（cAMP）水平增加约一倍。在EIA患者中，血浆cAMP的增加与Sgaw的降低呈负相关。我们的研究不支持早期的观点，即EIA中儿茶酚胺对运动的过度反应通过α-肾上腺素能受体刺激导致运动后支气管收缩。研究结果的差异似乎有方法学上的解释。
