Pohl R, Pandey G N, Yeragani V K, Balon R, Davis J M, Berchou R
Wayne State University, Detroit, MI.
Psychopharmacology (Berl). 1993;110(1-2):37-44. doi: 10.1007/BF02246948.
To examine whether a tricyclic antidepressant affects the functional response to a beta-receptor agonist in man, the response of heart rate, blood pressure, and plasma cAMP to isoproterenol was measured in 14 normal controls taking 75 mg desipramine daily. Desipramine significantly increased the bolus dose of isoproterenol needed to increase heart rate by 25 bpm at 14-30 days but not at 3-8 days. During infusions of isoproterenol, the increase in systolic blood pressure was blunted at both 3-8 days and 14-30 days, while the decrease in diastolic blood pressure was unaffected. Blood pressure findings were not affected by preadministration of bethanechol. In ten controls, isoproterenol infusions increased plasma cAMP, but this was unaffected by desipramine treatment. These findings suggest a decrease in the functional response of beta 1, but not beta 2, receptors after treatment with desipramine.
为研究三环类抗抑郁药是否会影响人体对β受体激动剂的功能反应，对14名每日服用75毫克去甲丙咪嗪的正常对照者，测量了其心率、血压及血浆环磷腺苷（cAMP）对异丙肾上腺素的反应。在14至30天，去甲丙咪嗪显著增加了使心率增加25次/分钟所需的异丙肾上腺素推注剂量，但在3至8天未出现这种情况。在输注异丙肾上腺素期间，收缩压在3至8天和14至30天均升高缓慢，而舒张压降低不受影响。血压结果不受氨甲酰甲胆碱预处理的影响。在10名对照者中，异丙肾上腺素输注使血浆cAMP增加，但这不受去甲丙咪嗪治疗的影响。这些发现表明，去甲丙咪嗪治疗后β1受体而非β2受体的功能反应降低。
