Department of Chemistry and Biochemistry, Queens College-CUNY, 65-30 Kissena Blvd., Queens, NY, 11367, USA.
Ph.D. Program in Chemistry and Ph.D. Program in Biochemistry, The Graduate Center of the City University of New York, New York, NY, 10016, USA.
Chembiochem. 2018 Sep 4;19(17):1806-1809. doi: 10.1002/cbic.201800257. Epub 2018 Jul 23.
Protein arginine deiminases (PADs) have recently emerged at the forefront of drug-discovery programs for several human disorders. Despite this, a precise understanding of their functional roles in human biology remains to be fully elucidated. This report highlights a recent development of next-generation activity-based PAD probes that are highly efficient, cell active, and metabolically stable. This discovery should rapidly expedite functional assignments of PAD biology in both normal and diseased cells, thereby leading to the development of PAD-targeted therapeutics in the near future.
精氨酸脱亚氨酶（PAD）最近成为了几种人类疾病药物研发计划的前沿领域。尽管如此，它们在人类生物学中的功能作用仍有待充分阐明。本报告重点介绍了新一代基于活性的 PAD 探针的最新进展，这些探针具有高效、细胞活性和代谢稳定性。这一发现应该会迅速加速 PAD 生物学在正常和患病细胞中的功能分配，从而在不久的将来开发出针对 PAD 的治疗方法。
