Ishikawa Tomofumi, Obara Taku, Nishigori Hidekazu, Nishigori Toshie, Metoki Hirohito, Ishikuro Mami, Tatsuta Nozomi, Mizuno Satoshi, Sakurai Kasumi, Nishijima Ichiko, Murai Yuriko, Fujiwara Ikuma, Arima Takahiro, Nakai Kunihiko, Yaegashi Nobuo, Kuriyama Shinichi, Mano Nariyasu
Laboratory of Clinical Pharmacy, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan.
Environment and Genome Research Center, Tohoku University Graduate School of Medicine, Sendai, Japan.
J Matern Fetal Neonatal Med. 2020 Feb;33(3):427-436. doi: 10.1080/14767058.2018.1494712. Epub 2018 Aug 19.
To provide the latest and most promising evidence on the prevalence and determinants for folic acid supplementation in pregnant women in Japan, including differences in prevalence between interview years and determinants across regions. The study participants were enrolled from 15 regional centers across Japan between January 2011 and March 2014. Information on the use of folic acid supplementation before and during pregnancy and the characteristics of the participants were collected using questionnaires, medical chart reviews, and interviews by research coordinators. Data for 91,538 women who provided sufficient data on folic acid supplementation were analyzed. The prevalence of adequate users was 8.0%, which, although low, tended to improve over the 4-year recruitment period. Various kinds of sociodemographic factors, lifestyle habits, and obstetrical and medication use history were significant and independent determinants for folic acid use. Associations between adequate preconception folic acid use and its major determinants tended to be similar across regions. Although the prevalence of adequate folic acid use was low, it increased from 2011 to 2014. Reproductive-aged women who have determinants for inadequate folic acid use should be informed about the need for preconception folic acid supplementation to help prevent neural tube defects.
为提供有关日本孕妇叶酸补充剂的患病率及其决定因素的最新且最有前景的证据，包括不同访谈年份之间患病率的差异以及各地区的决定因素。研究参与者于2011年1月至2014年3月期间从日本各地的15个区域中心招募。通过问卷调查、病历审查以及研究协调员的访谈收集了有关孕期前后叶酸补充剂使用情况及参与者特征的信息。对91538名提供了足够叶酸补充剂数据的女性的数据进行了分析。充足使用者的患病率为8.0%，尽管该患病率较低，但在4年的招募期内有上升趋势。各种社会人口学因素、生活习惯以及产科和用药史都是叶酸使用的重要且独立的决定因素。各地区孕前叶酸充足使用与其主要决定因素之间的关联往往相似。尽管叶酸充足使用的患病率较低，但从2011年到2014年有所上升。对于那些有叶酸使用不足决定因素的育龄妇女，应告知其孕前补充叶酸以预防神经管缺陷的必要性。
