Yang Jie, Kong Pengzhou, Yang Jian, Jia Zhiwu, Hu Xiaoling, Wang Zianyi, Cui Heyang, Bi Yanghui, Qian Yu, Li Hongyi, Wang Fang, Yang Bin, Yan Ting, Ma Yanchun, Zhang Ling, Cheng Caixia, Song Bin, Li Yaoping, Xu Enwei, Liu Haiyan, Gao Wei, Wang Juan, Liu Yiqian, Zhai Yuanfang, Chang Lu, Wang Yi, Zhang Yingchun, Shi Ruyi, Liu Jing, Wang Qi, Cheng Xiaolong, Cui Yongping
1 Translational Medicine Research Center, Shanxi Medical University, Taiyuan, Shanxi, PR China.
2 Key Laboratory of Cellular Physiology, Ministry of Education, Shanxi Medical University, Taiyuan, Shanxi, PR China.
Technol Cancer Res Treat. 2018 Jan 1;17:1533033818781405. doi: 10.1177/1533033818781405.
Esophageal squamous cell carcinoma is the sixth most lethal cancer worldwide and the fourth most lethal cancer in China. Tissue-specific transplantation antigen P35B codifies the enzyme GDP-d-mannose-4,6-dehydratase, which participates in the biosynthesis of GDP-l-fucose. GDP-l-fucose is an important substrate involved in the biosynthesis of many glycoproteins. Cancer cells are often accompanied by the changes in glycoprotein structure, which affects the adhesion, invasion, and metastasis of cells. It is not clear whether tissue-specific transplantation antigen P35B has any effect on the development of esophageal squamous cell carcinoma. We used an immunohistochemical method to assess the expression of tissue-specific transplantation antigen P35B in 104 esophageal squamous cell carcinoma samples. The results showed tissue-specific transplantation antigen P35B expression was associated with some clinical features in patients, such as age ( P = .017), clinical stage ( P = .010), and lymph node metastasis ( P = .043). Kaplan-Meier analysis and log-rank test showed that patients with esophageal squamous cell carcinoma having high tissue-specific transplantation antigen P35B expression had a worse prognosis compared to the patients with low expression ( P = .048). Multivariate Cox proportional hazards regression model showed that high expression of tissue-specific transplantation antigen P35B could predict poor prognosis for patients with esophageal squamous cell carcinoma independently. In conclusion, abnormal fucosylation might participate in the progress of esophageal squamous cell carcinoma and tissue-specific transplantation antigen P35B may serve as a novel biomarker for prognosis of patients with esophageal squamous cell carcinoma.
食管鳞状细胞癌是全球第六大致命性癌症，在中国是第四大致命性癌症。组织特异性移植抗原P35B编码GDP - D - 甘露糖 - 4,6 - 脱水酶，该酶参与GDP - L - 岩藻糖的生物合成。GDP - L - 岩藻糖是许多糖蛋白生物合成中涉及的重要底物。癌细胞常伴有糖蛋白结构的变化，这会影响细胞的黏附、侵袭和转移。目前尚不清楚组织特异性移植抗原P35B对食管鳞状细胞癌的发展是否有任何影响。我们采用免疫组化方法评估了104例食管鳞状细胞癌样本中组织特异性移植抗原P35B的表达情况。结果显示，组织特异性移植抗原P35B的表达与患者的一些临床特征相关，如年龄（P = .017）、临床分期（P = .010）及淋巴结转移（P = .043）。Kaplan - Meier分析和对数秩检验表明，组织特异性移植抗原P35B高表达的食管鳞状细胞癌患者预后较低表达患者更差（P = .048）。多变量Cox比例风险回归模型显示，组织特异性移植抗原P35B的高表达可独立预测食管鳞状细胞癌患者的不良预后。总之，异常岩藻糖基化可能参与食管鳞状细胞癌的进展，组织特异性移植抗原P35B可能作为食管鳞状细胞癌患者预后的一种新型生物标志物。
