Yu Jinyan, Li Yanlei, Zhang Qinghua, Wang Yan
Department of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, Jilin, 130000, People's Republic of China.
Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, Jilin, 130000, People's Republic of China.
Infect Drug Resist. 2025 Sep 4;18:4689-4697. doi: 10.2147/IDR.S534490. eCollection 2025.
In recent years, reports of hypervirulent (hv) carbapenem-resistant (CR) (Kp) (hv-CRKp) have gradually increased. hv-CRKp may emerge from hvKp acquiring mobile genetic elements carrying multiple antibiotic-resistance genes or multi-drug-resistant Kp acquiring virulence genes, with subsequent convergence of resistance and virulence. Thus, hv-CRKp simultaneously harbors resistance and virulence genes and may even show resistance to colistin and tigecycline, suggesting potential for causing severe infections and placing a serious burden on the health care system. In this study, we review and summarize published literature on the epidemiology, virulence, resistance genes, and treatment of hv-CRKp.
近年来，高毒力碳青霉烯耐药肺炎克雷伯菌（hv-CRKp）的报告逐渐增多。hv-CRKp可能源于高毒力肺炎克雷伯菌（hvKp）获得携带多种抗生素耐药基因的可移动遗传元件，或多重耐药肺炎克雷伯菌获得毒力基因，随后耐药性和毒力发生趋同。因此，hv-CRKp同时携带耐药基因和毒力基因，甚至可能对黏菌素和替加环素耐药，这表明其有可能导致严重感染，并给医疗保健系统带来沉重负担。在本研究中，我们回顾并总结了已发表的关于hv-CRKp的流行病学、毒力、耐药基因和治疗的文献。
