深入了解区域蛋白聚糖代谢在胸主动脉瘤中的作用 - Suppr

Insights Into the Role of Regional Proteoglycan Metabolism in Thoracic Aortic Aneurysms.

作者信息

Brasier Allan R

机构信息

From the Institute for Clinical and Translational Research, School of Medicine and Public Health, University of Wisconsin-Madison.

出版信息

Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1425-1426. doi: 10.1161/ATVBAHA.118.311120.

DOI:10.1161/ATVBAHA.118.311120

PMID:29950384

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6039411/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f01/6039411/86237b8eadcd/atv-38-1425-g001.jpg

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Insights Into the Role of Regional Proteoglycan Metabolism in Thoracic Aortic Aneurysms.深入了解区域蛋白聚糖代谢在胸主动脉瘤中的作用

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Increased tissue microarray matrix metalloproteinase expression favors proteolysis in thoracic aortic aneurysms and dissections.组织微阵列基质金属蛋白酶表达增加有利于胸主动脉瘤和夹层中的蛋白水解。

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Massive aggrecan and versican accumulation in thoracic aortic aneurysm and dissection.胸主动脉瘤和夹层中大量聚集的聚集蛋白聚糖和软骨寡聚基质蛋白。

JCI Insight. 2018 Mar 8;3(5):97167. doi: 10.1172/jci.insight.97167.

Therapeutics Targeting Drivers of Thoracic Aortic Aneurysms and Acute Aortic Dissections: Insights from Predisposing Genes and Mouse Models.针对胸主动脉瘤和急性主动脉夹层驱动因素的治疗方法：来自易感基因和小鼠模型的见解

Annu Rev Med. 2017 Jan 14;68:51-67. doi: 10.1146/annurev-med-100415-022956.

Cytokine amplification and macrophage effector functions in aortic inflammation and abdominal aortic aneurysm formation.细胞因子扩增与巨噬细胞效应功能在主动脉炎症及腹主动脉瘤形成中的作用

J Thorac Dis. 2016 Aug;8(8):E746-54. doi: 10.21037/jtd.2016.06.37.

Mechanical stretch-induced endoplasmic reticulum stress, apoptosis and inflammation contribute to thoracic aortic aneurysm and dissection.机械牵张诱导的内质网应激、细胞凋亡和炎症促成胸主动脉瘤和主动脉夹层形成。

J Pathol. 2015 Jul;236(3):373-83. doi: 10.1002/path.4534. Epub 2015 Apr 27.

Computational modelling suggests good, bad and ugly roles of glycosaminoglycans in arterial wall mechanics and mechanobiology.计算模型表明糖胺聚糖在动脉壁力学和机械生物学中具有好、坏和丑的作用。

J R Soc Interface. 2014 Aug 6;11(97):20140397. doi: 10.1098/rsif.2014.0397.

Cell biology. Dysfunctional mechanosensing in aneurysms.细胞生物学。动脉瘤中的机械传感功能障碍。

Science. 2014 May 2;344(6183):477-9. doi: 10.1126/science.1253026.

Structure, function and regulation of versican: the most abundant type of proteoglycan in the extracellular matrix.多功能蛋白聚糖的结构、功能与调控：细胞外基质中最为丰富的蛋白聚糖类型

Acta Med Iran. 2013;51(11):740-50.

Epidemiology of thoracic aortic dissection.胸主动脉夹层的流行病学。

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Proteomics characterization of extracellular space components in the human aorta.人主动脉细胞外腔室成分的蛋白质组学特征描述。

Mol Cell Proteomics. 2010 Sep;9(9):2048-62. doi: 10.1074/mcp.M110.001693. Epub 2010 Jun 15.

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Insights Into the Role of Regional Proteoglycan Metabolism in Thoracic Aortic Aneurysms.

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