Zagon I S, McLaughlin P J
Eur J Pharmacol. 1985 Jul 11;113(1):115-20. doi: 10.1016/0014-2999(85)90350-4.
The effects of (+) and (-) isomers of naloxone in altering tumor response in A/Jax mice inoculated with S20Y neuroblastoma were determined. Mice given daily subcutaneous injections of 15 mg/kg (-)naloxone had a 71% tumor incidence, a 33% delay in the time before tumor appearance, and a 28% increase in survival time. Inoculation of neuroblastoma cells in control subjects resulted in 100% tumor incidence within 13 days. Animals given 15 mg/kg (+)naloxone were comparable to control subjects in all aspects of neural neoplasia. These results show that opioid antagonists exert a stereospecific action on neural cancers, and provide further evidence that endogenous opioid systems play an important role in neuro-oncogenic expression.
测定了纳洛酮的（+）和（-）异构体对接种S20Y神经母细胞瘤的A/Jax小鼠肿瘤反应的影响。每天皮下注射15mg/kg（-）纳洛酮的小鼠肿瘤发生率为71%，肿瘤出现前的时间延迟33%，存活时间增加28%。对照组接种神经母细胞瘤细胞后13天内肿瘤发生率为100%。给予15mg/kg（+）纳洛酮的动物在神经肿瘤形成的各个方面与对照组相当。这些结果表明阿片类拮抗剂对神经癌具有立体特异性作用，并进一步证明内源性阿片系统在神经肿瘤发生表达中起重要作用。
