基因变异是印度北部人群术后房颤的一个预测指标。

gene variant a predictor of postoperative atrial fibrillation in the north Indian population.

作者信息

Yadav Surabhi, Akhtar Salman, Agarwal Surendra K, Majumdar Gauranga, Vimal Suman, Sharma Mala

机构信息

Department of Bioengineering/Biosciences Integral University Lucknow India.

Department of Cardiovascular and Thoracic Surgery Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India.

出版信息

J Arrhythm. 2018 May 22;34(3):281-285. doi: 10.1002/joa3.12074. eCollection 2018 Jun.

DOI:10.1002/joa3.12074

PMID:29951144

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6009777/

Abstract

BACKGROUND

There is an accumulating body of evidence indicating a strong association between inflammation and the pathogenesis of atrial fibrillation (AF) in different ethnicities across the globe. AF increases the risk of stroke and heart failure. Despite various researches on response, there is limited clinical evidence present, which demonstrate a role of these immunity regulators in AF. Therefore, this study was designed to decipher the role of polymorphism in the development of postoperative AF (post-OP AF).

METHOD

The study was designed for north Indian patients. The study included 90 patients with AF and 126 controls in sinus rhythm undergoing surgery at Department of Cardiovascular and thoracic surgery, SGPGIMS, Lucknow, India. DNA samples were genotyped for common single nucleotide polymorphism (SNP) in gene . The PCR-based RFLP technique was used to assess the genotype frequencies. The multivariable logistic regression analysis was performed to study the association of other risk factors with AF.

RESULTS

The distribution of genotypes (CC, AC, and AA) was found to be 48.41%, 47.61%, and 3.98% in controls and 41.11%, 45.55%, and 13.34% in cases, respectively ( = .0385). The frequency of allele A in cases was significantly higher than the control group (36.11% vs 27.77%, = .0654). Compared with CC, AA genotype had increased risk of AF in both unadjusted and adjusted analyses.

CONCLUSIONS

This study suggests that polymorphism may have significant association with post-OP AF development in north Indian patients.

摘要

背景

越来越多的证据表明，在全球不同种族中，炎症与心房颤动（AF）的发病机制之间存在密切关联。AF会增加中风和心力衰竭的风险。尽管对相关反应进行了各种研究，但目前临床证据有限，无法证明这些免疫调节因子在AF中的作用。因此，本研究旨在阐明多态性在术后心房颤动（术后AF）发生发展中的作用。

方法

该研究针对印度北部患者设计。研究纳入了90例AF患者和126例在印度勒克瑙SGPGIMS心血管和胸外科接受手术的窦性心律对照组。对基因中的常见单核苷酸多态性（SNP）进行DNA样本基因分型。采用基于聚合酶链反应（PCR）的限制性片段长度多态性（RFLP）技术评估基因型频率。进行多变量逻辑回归分析以研究其他危险因素与AF的关联。

结果

对照组中基因型（CC、AC和AA）的分布分别为48.41%、47.61%和3.98%，病例组中分别为41.11%、45.55%和13.34%（P = 0.0385）。病例组中等位基因A的频率显著高于对照组（36.11%对27.77%，P = 0.0654）。与CC相比，AA基因型在未调整和调整分析中AF风险均增加。