Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Svante Arrhenius vag 20C, 10691 Stockholm, Sweden.
Clinical Oncology Laboratory, Department of Oncology, Changzhou Tumour Hospital Affiliated to Suzhou University, Honghe Road No. 68, Xinbei Area, Changzhou 213032, China.
Oxid Med Cell Longev. 2018 May 23;2018:4153574. doi: 10.1155/2018/4153574. eCollection 2018.
The level of oxidative stress is important in the initiation and progression of various age-related diseases, such as cancer. The level of oxidative stress may also play a significant role in cancer patients' response to treatment. We aimed to investigate whether serum 8-oxo-dG as a marker of oxidative stress is a predictor of tumour response. We used modified ELISA with a two-step filtration to analyse 8-oxo-dG in serum. The relationship between 8-oxo-dG levels, tumour response, and toxicity was studied in 19 oesophageal cancer patients who received radiotherapy and 16 gastric cancer patients who received chemotherapy. In the radiotherapy and the merged radio- and chemotherapy groups, the baseline levels of 8-oxo-dG were significantly lower in responder patients than in nonresponder patients and the increments after treatment were greater. In comparison with patients whose serum 8-oxo-dG levels decrease after treatment, patients with increasing levels had a longer median "progression-free survival." Our results, although preliminary, suggest that serum levels of 8-oxo-dG may potentially be used to predict the sensitivity and outcome of radiotherapy and chemotherapy of upper gastrointestinal tumours. Patients with 8-oxo-dG levels that are low prior to treatment and subsequently increase after treatment may be more likely to benefit from the therapy.
氧化应激水平在各种与年龄相关的疾病（如癌症）的发生和发展中很重要。氧化应激水平也可能在癌症患者对治疗的反应中起重要作用。我们旨在研究血清 8-氧代-dG 作为氧化应激标志物是否可预测肿瘤反应。我们使用两步过滤的改良 ELISA 分析血清中的 8-氧代-dG。我们研究了 19 例接受放疗的食管癌患者和 16 例接受化疗的胃癌患者的 8-氧代-dG 水平、肿瘤反应和毒性之间的关系。在放疗和合并放化疗组中，与无反应患者相比，反应患者的基线 8-氧代-dG 水平显著降低，治疗后的增加幅度更大。与治疗后血清 8-氧代-dG 水平下降的患者相比，水平升高的患者中位“无进展生存期”更长。尽管我们的结果初步表明，血清 8-氧代-dG 水平可能可用于预测上消化道肿瘤放疗和化疗的敏感性和结果。治疗前水平较低、治疗后升高的患者可能更有可能从治疗中受益。
