Ambler G K, Mariam N B G, Sadat U, Coughlin P A, Loftus I M, Boyle J R
Division of Population Medicine Cardiff University Cardiff UK.
South East Wales Vascular Network, Aneurin Bevan University Health Board, Royal Gwent Hospital Newport UK.
BJS Open. 2017 Dec 4;1(5):158-164. doi: 10.1002/bjs5.24. eCollection 2017 Oct.
The 'weekend effect' describes the phenomenon where patient outcomes appear worse for those admitted at the weekend. It has been used recently to justify significant changes in UK health policy. Recent evidence has suggested that the effect may be due to a combination of inadequate correction for confounding factors and inaccurate coding. The effects of these factors were investigated in patients with acute abdominal aortic aneurysm (AAA).
Patients undergoing non-elective AAA repair entered into the UK National Vascular Registry from January 2013 until December 2015 were included in a case-control study. The patients were divided according to whether they were treated during the week (Monday 08.00 hours to Friday 17.00 hours) or at the weekend. Data extracted included demographics, co-morbidities, preoperative medications and baseline blood test results, as well as outcomes. Coding issues were investigated by looking at patients treated for ruptured, symptomatic or asymptomatic AAA within the non-elective cohort. The primary outcome was in-hospital mortality. Secondary outcomes included length of inpatient stay, and cardiac, respiratory and renal complications.
The mortality rate appeared to be higher at the weekend (odds ratio (OR) 1·69, 95 per cent c.i. 1·47 to 1·94; P < 0·001), but this effect disappeared when confounding factors and coding issues were corrected for (corrected OR for ruptured AAA 1·09, 0·92 to 1·29; P = 0·330). Differences in outcomes were similar for prolonged length of hospital stay (uncorrected OR 1·21, 95 per cent c.i. 1·06 to 1·37, P = 0·005; corrected OR for ruptured AAA 1·06, 0·91 to 1·10, P = 0·478), and morbidity outcomes.
After appropriate correction for confounding factors and coding effects, there was no evidence of a significant weekend effect in the treatment of non-elective AAA in the UK.
“周末效应”描述了一种现象,即周末入院的患者预后似乎更差。最近它被用于为英国卫生政策的重大变革提供依据。近期证据表明,这种效应可能是由于对混杂因素校正不足和编码不准确共同导致的。在急性腹主动脉瘤(AAA)患者中对这些因素的影响进行了调查。
纳入2013年1月至2015年12月进入英国国家血管登记处接受非选择性AAA修复的患者进行病例对照研究。患者根据是在工作日(周一08:00至周五17:00)还是在周末接受治疗进行分组。提取的数据包括人口统计学、合并症、术前用药和基线血液检查结果以及预后情况。通过观察非选择性队列中接受破裂、有症状或无症状AAA治疗的患者来调查编码问题。主要结局是住院死亡率。次要结局包括住院时间以及心脏、呼吸和肾脏并发症。
周末的死亡率似乎更高(优势比(OR)1.69,95%可信区间1.47至1.94;P<0.001),但在校正混杂因素和编码问题后这种效应消失了(破裂AAA的校正OR为1.09,0.92至1.29;P=0.330)。住院时间延长(未校正OR 1.21,95%可信区间1.06至1.37,P=0.005;破裂AAA的校正OR为1.06,0.91至1.10,P=0.478)以及发病结局方面的差异相似。
在对混杂因素和编码效应进行适当校正后,没有证据表明英国在非选择性AAA治疗中存在显著的周末效应。