Department of Chemistry, Indian Institute Technology Kharagpur, Kharagpur, India.
Org Biomol Chem. 2018 Jul 11;16(27):5027-5035. doi: 10.1039/c8ob01328d.
Asymmetric total synthesis of naturally occurring γ-butenolide containing [4.4]spiro-tetrahydrofuran lanceolactone A has been reported in the present work. Bimetallic ("Pd-Cu") cascade cyclization was the crucial reaction employed for the construction of the γ-butenolide framework of the natural product. Subsequently, iodocyclization and reductive deiodination through a transfer hydrogenation reaction were applied to access the target molecule in an efficient manner.
本文报道了天然存在的含[4.4]螺四氢呋喃裂环苍耳亭 A 的γ-丁烯内酯的不对称全合成。双金属（“Pd-Cu”）级联环化反应是构建天然产物γ-丁烯内酯骨架的关键反应。随后，通过转移氢化反应进行碘环化和还原脱碘，以高效的方式获得目标分子。
