有机催化串联 Morita-Baylis-Hillman-Michael 反应在手性合成氧杂螺环茚酮骨架药物中的应用。
Organocatalytic tandem Morita-Baylis-Hillman-Michael reaction for asymmetric synthesis of a drug-like oxa-spirocyclic indanone scaffold.
机构信息
State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P. R. China.
出版信息
Chem Commun (Camb). 2013 Oct 7;49(77):8692-4. doi: 10.1039/c3cc44004d.
PMID:23955114
Abstract
A novel multicatalytic MBH-Michael tandem reaction has been developed for the asymmetric assembly of ninhydrin, nitroolefins and aldehydes into a structurally complex oxa-spirocyclic indanone backbone. Successive iodocyclization allowed us to convert these multifunctional allylic products into fused chiral natural product mimics.
摘要
一种新型多酶 MBH-Michael 串联反应已被开发用于将内酰亚胺、硝基烯烃和醛不对称地组装成具有复杂结构的氧杂螺环茚酮骨架。连续的碘化环化反应使我们能够将这些多功能烯丙基产物转化为融合的手性天然产物类似物。
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