State Key Laboratory of Fine Chemicals, School of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian 116024, P. R. China.
Chem Commun (Camb). 2018 Jul 12;54(57):7928-7931. doi: 10.1039/c8cc03804j.
Novel and practical acid-catalyzed cyclization of 2-indolyl aryl carbinols via tandem dehydration/1,5-hydride shift/7-cyclization sequences has been developed. By appropriate variation of the substrate, diverse polycyclic-fused indoles were synthesized in good yield, thus demonstrating the high efficiency, transition-metal-free nature, and high step/atom economy of the synthesis strategy.
新型实用的酸催化 2-吲哚基芳基甲醇的串联脱水/1,5-氢化物转移/7-环化反应已被开发。通过适当改变底物，可以以良好的收率合成多种稠环融合的吲哚，从而证明了该合成策略的高效、无过渡金属和高步骤/原子经济性。
