Li Shuai-Shuai, Lv Xintong, Ren Didi, Shao Chang-Lun, Liu Qing, Xiao Jian
Shandong Province Key Laboratory of Applied Mycology , College of Chemistry and Pharmaceutical Sciences , Qingdao Agricultural University , Qingdao , 266109 , China . Email:
Key Laboratory of Marine Drugs , The Ministry of Education of China , School of Medicine and Pharmacy , Ocean University of China , Qingdao 266003 , China.
Chem Sci. 2018 Sep 13;9(43):8253-8259. doi: 10.1039/c8sc03339k. eCollection 2018 Nov 21.
An unprecedented cascade dearomative cyclization through hydrogen-bonding-assisted hydride transfer is realized. The aggregate effect of HFIP enables the rapid buildup of polycyclic amines directly from phenols and -aminobenzaldehydes a cascade dearomatization/rearomatization/dearomatization sequence. This unique transformation addressed the drawbacks of hydride transfer-involved redox-neutral reactions.
通过氢键辅助的氢化物转移实现了前所未有的级联去芳构化环化反应。六氟异丙醇（HFIP）的聚集效应能够使多环胺直接从苯酚和对氨基苯甲醛快速生成——这是一个级联去芳构化/再芳构化/去芳构化序列。这种独特的转化解决了涉及氢化物转移的氧化还原中性反应的缺点。
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