Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Dig Dis Sci. 2018 Aug;63(8):2022-2027. doi: 10.1007/s10620-018-5164-7.
In this study, we argue that the basic clonal unit that makes up the Barrett's segment is at the level of the gland. There is expansion of this clonal unit, the gland, by fission, and there is evidence that the Barrett's segment is itself a clonal proliferation. Barrett's esophagus arises from both goblet cell-containing metaplasia and non-goblet cell-containing metaplasia and may arise from a stable clone, but the genomic changes occurring are subject to selection, usually with little or no evolution, appearing indolent from the evolutionary perspective. Genomic changes leading to dysplastic phenotypes are selected, but without any single clone predominating within the segment.
在这项研究中，我们认为构成 Barrett 段的基本克隆单位是在腺体水平。这个克隆单位（腺体）通过分裂进行扩张，并且有证据表明 Barrett 段本身就是克隆性增殖。Barrett 食管源于含有杯状细胞的化生和不含杯状细胞的化生，可能来自于一个稳定的克隆，但发生的基因组变化受到选择，通常很少或没有进化，从进化的角度来看是惰性的。导致发育不良表型的基因组变化被选择，但在该段内没有任何单一克隆占主导地位。
