肠稳态和癌症中的干细胞动力学。
Stem cell dynamics in homeostasis and cancer of the intestine.
机构信息
1] Laboratory for Experimental Oncology and Radiobiology, Center for Experimental Molecular Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. [2] Cancer Research UK - Cambridge Institute, University of Cambridge, Robinson Way, CB2 0RE, Cambridge, UK.
Molecular Cancer Research and Cancer Genomics Netherlands, Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.
出版信息
Nat Rev Cancer. 2014 Jul;14(7):468-80. doi: 10.1038/nrc3744. Epub 2014 Jun 12.
Intestinal stem cells (ISCs) and colorectal cancer (CRC) biology are tightly linked in many aspects. It is generally thought that ISCs are the cells of origin for a large proportion of CRCs and crucial ISC-associated signalling pathways are often affected in CRCs. Moreover, CRCs are thought to retain a cellular hierarchy that is reminiscent of the intestinal epithelium. Recent studies offer quantitative insights into the dynamics of ISC behaviour that govern homeostasis and thereby provide the necessary baseline parameters to begin to apply these analyses during the various stages of tumour development.
肠干细胞（ISCs）和结直肠癌（CRC）生物学在许多方面紧密相关。人们普遍认为 ISCs 是大部分 CRC 的起源细胞，并且 CRC 中经常会受到关键的 ISC 相关信号通路的影响。此外，CRC 被认为保留了类似于肠上皮的细胞层次结构。最近的研究提供了关于 ISC 行为动力学的定量见解，这些见解可以控制体内平衡，从而为在肿瘤发展的各个阶段开始应用这些分析提供必要的基线参数。
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