Institute of Clinical Neuroscience, "Juhász Pál" Epilepsy Centrum, Amerikai út 57, Budapest, 1145, Hungary.
Institute of Behavioural Sciences, Semmelweis University, Nagyvárad tér 4, Budapest, 1089, Hungary.
Brain Struct Funct. 2018 Nov;223(8):3531-3542. doi: 10.1007/s00429-018-1703-4. Epub 2018 Jun 27.
Slow waves recorded with EEG in NREM sleep are indicative of the strength and spatial extent of synchronized firing in neuronal assemblies of the cerebral cortex. Slow waves often appear in the A1 part of the cyclic alternating patterns (CAP), which correlate with a number of behavioral and biological parameters, but their physiological significance is not adequately known. We automatically detected slow waves from the scalp recordings of 37 healthy patients, visually identified CAP A1 events and compared slow waves during CAP A1 with those during NCAP. For each slow wave, we computed the amplitude, slopes, frequency, synchronization (synchronization likelihood) between specific cortical areas, as well as the location of origin and scalp propagation of individual waves. CAP A1 slow waves were characterized by greater spatial extent and amplitude, steeper slopes and greater cortical synchronization, but a similar prominence in frontal areas and similar propagation patterns to other areas on the scalp. Our results indicate that CAP A1 represents a period of highly synchronous neuronal firing over large areas of the cortical mantle. This feature may contribute to the role CAP A1 plays in both normal synaptic homeostasis and in the generation of epileptiform phenomena in epileptic patients.
在非快速眼动睡眠期间记录到的慢波表明大脑皮层神经元集合的同步放电强度和空间范围。慢波通常出现在周期性交替模式 (CAP) 的 A1 部分，与许多行为和生物学参数相关，但它们的生理意义尚未得到充分了解。我们从 37 名健康患者的头皮记录中自动检测慢波，视觉识别 CAP A1 事件，并比较 CAP A1 期间的慢波与非 CAP A1 期间的慢波。对于每个慢波，我们计算了振幅、斜率、频率、特定皮质区域之间的同步（同步可能性），以及单个波的起源位置和头皮传播。CAP A1 慢波的特征是空间范围更大、振幅更大、斜率更陡、皮质同步性更强，但在前额区域的突出程度相似，与头皮上其他区域的传播模式相似。我们的结果表明，CAP A1 代表了大脑皮层覆盖区域中高度同步的神经元放电期。这一特征可能有助于 CAP A1 在正常突触稳态和癫痫患者癫痫样现象的产生中发挥作用。
