Center for Neural Science, New York University, 4 Washington Place, New York, NY, 10003, USA.
Child and Adolescent Psychiatry, New York State Psychiatric Institute, 1051 Riverside Dr, New York, NY, 10032, USA.
Brain Struct Funct. 2018 Nov;223(8):3543-3556. doi: 10.1007/s00429-018-1704-3. Epub 2018 Jun 27.
Patients with neuropsychiatric and neurological disorders often express limbic circuit abnormalities and deficits in information processing. While these disorders appear to have diverse etiologies, their common features suggest neurodevelopmental origins. Neurodevelopment is a prolonged process of diverse events including neurogenesis/apoptosis, axon pathfinding, synaptogenesis, and pruning, to name a few. The precise timing of the neurodevelopmental insult to these processes likely determines the resulting functional outcome. We used the epilepsy and schizophrenia-related gestational day 17 methylazoxymethanol acetate model to examine the impact of this timed neurodevelopmental insult on principal cell morphology and synaptic network function of the dorsal hippocampus (dHPC) circuit. Our observed structural and functional alterations in dHPC are compartment specific, indicating that adverse global exposure during gestation can produce specific alterations and distort information processing in neural circuits that underlie cognitive abilities.
患有神经精神和神经疾病的患者常常表现出边缘回路异常和信息处理缺陷。虽然这些疾病似乎有不同的病因，但它们的共同特征表明其起源于神经发育。神经发育是一个复杂的过程，包括神经发生/凋亡、轴突寻路、突触形成和修剪等多种事件。这些过程中神经发育损伤的精确时间可能决定了最终的功能结果。我们使用与癫痫和精神分裂症相关的妊娠第 17 天甲基乙氧甲酰乙酸模型，来研究这种定时神经发育损伤对背侧海马（dHPC）回路的主要细胞形态和突触网络功能的影响。我们观察到 dHPC 的结构和功能改变具有特定的区域特异性，这表明妊娠期间的不利的全身性暴露可以产生特定的改变，并扭曲认知能力相关的神经回路中的信息处理。
