Department of Pediatric of Rheumatology, Pamukkale University School of Medicine, Pamukkale, Denizli, Turkey.
Rheumatol Int. 2018 Aug;38(8):1577-1584. doi: 10.1007/s00296-018-4088-z. Epub 2018 Jun 27.
An acquired form of angioedema that is clinically similar but scarcer than the hereditary form may be caused, even more rarely, by the presence of an underlying autoimmune disease. We report a previously healthy 16-year-old girl with an acquired angioedema as a rare and initial presentation of systemic lupus erythematosus. The patient had no previous angioedema attack and no family history. She did not have any chronic diseases and did not use any medicine regularly. The patient was diagnosed with systemic lupus erythematosus with the presence of polyarthralgia, angioedema, leucopenia, and positivity of immunologic criteria. Her edema resolved with high-dose methylprednisolone and hydroxychloroquine slowly. In conclusion, new-onset angioedema in adolescent girls should be investigated to evaluate autoimmunity and the possibility of systemic lupus erythematosus. The related literature on acquired angioedema associated with systemic lupus erythematosus is also reviewed.
一种获得性血管性水肿，其临床表现与遗传性血管性水肿相似，但较为罕见，可能由潜在自身免疫性疾病引起。我们报告了一例既往健康的 16 岁女孩，以获得性血管性水肿为系统性红斑狼疮的罕见首发表现。该患者以前无血管性水肿发作，无家族史，无任何慢性疾病，也不规律使用任何药物。该患者诊断为系统性红斑狼疮，伴多发性关节炎、血管性水肿、白细胞减少和免疫标准阳性。她的水肿用大剂量甲基强的松龙和羟氯喹缓慢消退。总之，青少年女性新发血管性水肿应进行自身免疫和系统性红斑狼疮的可能性评估。还回顾了与系统性红斑狼疮相关的获得性血管性水肿的相关文献。
