Santos Guidyan Anne Silva, Boing Alexandra Crispim
Universidade Federal de Santa Catarina, Florianópolis, Brasil.
Cad Saude Publica. 2018 Jun 25;34(6):e00100917. doi: 10.1590/0102-311X00100917.
In recent years, drug poisoning and adverse reactions have been an important cause of hospitalization and mortality and a major public health issue. The aim of this study was to describe trends in hospitalizations and deaths from drug poisoning and adverse reactions from 2000 to 2014. Data were from the Mortality Information System (SIM) and Information System on Authorizations for Hospital Admissions of the Brazilian Unified National Health System (SIH-SUS), and the study population was analyzed by sex, region of residence, and age bracket. Events were defined according to ICD-10 codes. The analysis of trends in the historical series used Prais-Winsten generalized linear regression with correction for first order autocorrelation effect. Both the hospitalizations and deaths during the study period showed upward trends. The analysis by regions maintained the upward trends for both events in the South and Southeast regions. Analysis according to age brackets showed downward trends in children under five years in both events, upward trend in deaths in individuals over four years of age, and an upward trend in hospitalizations in the age bracket from 20 to 59 years. Drug poisoning and adverse reactions contribute significantly to hospitalizations and deaths in Brazil, and the SIM and SIH-SUS are data sources with satisfactory quality for population-based studies on hospital morbidity and mortality in the country.
近年来，药物中毒及不良反应一直是住院和死亡的重要原因，也是一个重大的公共卫生问题。本研究的目的是描述2000年至2014年期间药物中毒及不良反应导致的住院和死亡趋势。数据来自巴西统一国家卫生系统的死亡信息系统（SIM）和医院入院授权信息系统（SIH-SUS），并按性别、居住地区和年龄组对研究人群进行分析。事件根据国际疾病分类第十版（ICD-10）编码进行定义。对历史序列趋势的分析采用了Prais-Winsten广义线性回归，并对一阶自相关效应进行了校正。研究期间的住院和死亡人数均呈上升趋势。按地区分析显示，南部和东南部地区这两类事件均保持上升趋势。按年龄组分析显示，五岁以下儿童这两类事件呈下降趋势，四岁以上人群死亡呈上升趋势，20至59岁年龄组住院呈上升趋势。药物中毒及不良反应在巴西的住院和死亡中占很大比例，SIM和SIH-SUS是该国基于人群的医院发病率和死亡率研究中质量令人满意的数据源。
