Horakova Dagmar, Stepanek Ladislav, Nagelova Radka, Pastucha Dalibor, Azeem Katerina, Kollarova Helena
Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 775 15 Olomouc, Czech Republic.
Endokrynol Pol. 2018;69(4):375-380. doi: 10.5603/EP.a2018.0035. Epub 2018 Jun 28.
Adiponectin is a peptide secreted by adipocytes; its reduction is associated with obesity-related disorders, including insulin resistance (IR). The study analysed levels of total adiponectin and its high-molecular-weight (HMW) oligomer in a group of metabolically healthy adults and in patients with type 2 diabetes mellitus (T2DM) to evaluate these levels as potential predictors of the presence of IR.
The study comprised 269 metabolically healthy adults and 300 patients with T2DM. Anthropometric and bio-chemical indices were measured, including total and HMW adiponectin levels; the Homeostatic Model Assessment of IR (HOMA-IR) index was calculated, and logistic regression analysis was used to predict the presence of IR.
In healthy individuals, both total and HMW adiponectin levels were significantly higher than in diabetic patients. Total and HMW adiponectin levels were moderately correlated with the HOMA-IR index. Logistic regression analysis showed that increased levels of both total adiponectin (odds ratio [OR] 0.598, 95% confidence interval [CI] 0.483-0.723) and the HMW form (OR 0.360, 95% CI 0.242-0.511) are protective factors for the development of IR. The cut-off levels were 4.22 mg/L for total adiponectin and 2.75 mg/L for HMW adiponectin. The results are valid for middle-aged European adults.
Adiponectin levels below the indicated cut-offs may predict a potential risk for the development of IR.
脂联素是一种由脂肪细胞分泌的肽；其水平降低与肥胖相关疾病有关，包括胰岛素抵抗（IR）。本研究分析了一组代谢健康的成年人以及2型糖尿病（T2DM）患者的总脂联素水平及其高分子量（HMW）寡聚体水平，以评估这些水平作为IR存在的潜在预测指标。
该研究纳入了269名代谢健康的成年人和300名T2DM患者。测量了人体测量学和生化指标，包括总脂联素和HMW脂联素水平；计算了IR的稳态模型评估（HOMA-IR）指数，并采用逻辑回归分析来预测IR的存在。
在健康个体中，总脂联素和HMW脂联素水平均显著高于糖尿病患者。总脂联素和HMW脂联素水平与HOMA-IR指数呈中度相关。逻辑回归分析表明，总脂联素水平升高（比值比[OR] 0.598，95%置信区间[CI] 0.483 - 0.723）和HMW形式水平升高（OR 0.360，95% CI 0.242 - 0.511）都是IR发生的保护因素。总脂联素的截断水平为4.22 mg/L，HMW脂联素为2.75 mg/L。研究结果适用于欧洲中年成年人。
低于所示截断水平的脂联素水平可能预示着IR发生的潜在风险。
