Stop TRPC5 in Kidney Disease: A Game Changer for Renal Allograft Protection?
作者信息
Wang Xuexiang, Reiser Jochen
机构信息
Department of Medicine, Rush University Medical Center, Chicago, IL.
出版信息
Transplantation. 2018 Jul;102(7):1027-1029. doi: 10.1097/TP.0000000000002209.
Abstract
摘要
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Stop TRPC5 in Kidney Disease: A Game Changer for Renal Allograft Protection?阻断肾脏疾病中的瞬时受体电位阳离子通道亚家族5：肾移植保护的变革者？
Transplantation. 2018 Jul;102(7):1027-1029. doi: 10.1097/TP.0000000000002209.
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A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models.TRPC5离子通道的小分子抑制剂可抑制动物模型中的进行性肾病。
Science. 2017 Dec 8;358(6368):1332-1336. doi: 10.1126/science.aal4178.
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TRPC5 Does Not Cause or Aggravate Glomerular Disease.TRPC5 不会导致或加重肾小球疾病。
J Am Soc Nephrol. 2018 Feb;29(2):409-415. doi: 10.1681/ASN.2017060682. Epub 2017 Oct 23.
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Recurrent IgA Nephropathy After Kidney Transplantation.肾移植后复发性IgA肾病
Transplantation. 2016 Sep;100(9):1827-32. doi: 10.1097/TP.0000000000001093.
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MicroRNA-30 family members regulate calcium/calcineurin signaling in podocytes.微小RNA-30家族成员调节足细胞中的钙/钙调神经磷酸酶信号传导。
J Clin Invest. 2015 Nov 2;125(11):4091-106. doi: 10.1172/JCI81061. Epub 2015 Oct 5.
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Inhibition of the TRPC5 ion channel protects the kidney filter.抑制 TRPC5 离子通道可保护肾脏滤器。
J Clin Invest. 2013 Dec;123(12):5298-309. doi: 10.1172/JCI71165. Epub 2013 Nov 15.
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Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels.TRPC5 和 TRPC6 通道对肌动蛋白动态和细胞迁移的拮抗调节。
Sci Signal. 2010 Oct 26;3(145):ra77. doi: 10.1126/scisignal.2001200.
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TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology.足细胞中 TRPC6 通道及其结合伴侣：在肾小球滤过和病理生理学中的作用。
Am J Physiol Renal Physiol. 2010 Oct;299(4):F689-701. doi: 10.1152/ajprenal.00298.2010. Epub 2010 Aug 4.
8
Induction of TRPC6 channel in acquired forms of proteinuric kidney disease.获得性蛋白尿性肾病中瞬时受体电位阳离子通道6（TRPC6）通道的诱导
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TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function.瞬时受体电位阳离子通道亚家族C成员6（TRPC6）是一种与肾小球裂孔隔膜相关的通道，是正常肾功能所必需的。
Nat Genet. 2005 Jul;37(7):739-44. doi: 10.1038/ng1592. Epub 2005 May 27.
10
Catecholamines modulate podocyte function.儿茶酚胺调节足细胞功能。
J Am Soc Nephrol. 1998 Mar;9(3):335-45. doi: 10.1681/ASN.V93335.
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